1228019-07-5Relevant academic research and scientific papers
Syntheses and NMR characterizations of epimeric 4-deoxy-4-fluoro carbohydrates
Subotkowski, Witold,Friedrich, Dirk,Weiberth, Franz J.
scheme or table, p. 2323 - 2326 (2011/12/04)
The synthesis and NMR characterizations of 1,2,3,6-tetra-O-benzoyl-4-deoxy- 4-fluoro-β-D-galactopyranoside, the 4-deoxy-4-fluoro epimer of an intermediate in the synthesis of a drug substance, needed for use as a potential impurity standard and to confirm the stereoselectivity of a key fluorination step, are described.
Process development of selectively benzoylated and fluorinated glycosyl donors
Weiberth, Franz J.,Gill, Harpal S.,Jiang, Ying,Lee, George E.,Lienard, Philippe,Pemberton, Clive,Powers, Matthew R.,Subotkowski, Witold,Tomasik, Witold,Vanasse, Benoit J.,Yu, Yong
, p. 623 - 631 (2011/07/30)
Route selection, process development and large-scale preparation of selectively benzoylated and fluorinated d-glucopyranoses, required as glycosyl donors for the synthesis of the SGLT inhibitor SAR7226, are discussed.
INTERMEDIATES AND PROCESSES FOR THE PREPARATION OF FLUOROGLYCOSIDE DERIVATIVES
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Page/Page column 32; 33, (2010/08/04)
The present invention provides processes for producing (2S,3R,4R,5S,6R)-5-fluoro-6- hydroxymethyl-2-[4-(4-methoxy-benzyl)-5-trifluoromethyl-1H-pyrazol-3-yloxy]- tetrahydro-pyran-3,4-diol or a tautomer or hydrate thereof, of high purity and in a relatively
