1228104-24-2Relevant academic research and scientific papers
Asymmetric total synthesis of (+)-Hexachlorosulfolipid, a cytotoxin isolated from adriatic mussels
Yoshimitsu, Takehiko,Fukumoto, Naoya,Nakatani, Ryo,Kojima, Naoto,Tanaka, Tetsuaki
experimental part, p. 5425 - 5437 (2010/11/03)
The enantioselective total synthesis of (+)-hexachlorosulfolipid, a cytotoxin found in the Adriatic mussel Mytilus galloprovincialis, is described. The unique chlorinated hydrocarbon motif of the lipid is successfully furnished by a series of dichlorination reactions of chiral epoxides with chlorophosphonium reagent generated in situ from Ph3P/NCS. The present total synthesis has allowed the confirmation of the absolute configuration of the natural cytotoxic (+)-hexachlorosulfolipid originally proposed by Fattorusso, Ciminiello, and co-workers.
