122822-48-4Relevant academic research and scientific papers
Reduction of titanocene dichloride with dysprosium: Access to a stable titanocene(II) equivalent for phosphite-free Takeda carbonyl olefination
Bousrez,Déchamps,Vasse,Jaroschik
, p. 9359 - 9362 (2015/06/16)
The reduction of titanocene dichloride with dysprosium yields a new titanocene(ii) equivalent without the need for further stabilising ligands. This reagent can be employed in combination with dithioacetals for the olefination of different carbonyl groups and allows for a simplified all-in-one procedure.
Conformational and structural analysis of exocyclic olefins and ketimines by multinuclear magnetic resonance
Montalvo-Gonzalez, Ruben,Montalvo-Gonzalez, J. Ascencion,Ariza-Castolo, Armando
experimental part, p. 907 - 912 (2009/05/09)
The 1H, 13C, and 15N NMR spectra of 5 exocyclic alkenes and 15 different ketimines obtained from cyclohexanone and derivatives using benzyl bromide and primary amines - are analyzed. Relative stereochemical and preferentia
3,5-Bis(trifluoromethyl)phenyl sulfones in the Julia-Kocienski olefination - Application to the synthesis of tri- and tetrasubstituted olefins
Alonso, Diego A.,Fuensanta, Monica,Najera, Carmen
, p. 4747 - 4754 (2007/10/03)
3,5-Bis(trifluoromethyl)phenyl (BTFP) sulfones 8a-d are successfully employed in the modified Julia olefination reaction with carbonyl compounds employing phosphazene base P4-tBu at room temp. in THF, affording tri- and tetrasubstituted olefins in good yi
A novel method for the preparation of benzylidenecyclohexanes with high optical purity
Nakamura, Shuichi,Ogura, Takahiro,Wang, Libo,Toru, Takeshi
, p. 2399 - 2402 (2007/10/03)
The enantioselective reaction of the α-thio carbanion derived from 1-phenyl-1-(phenylthio)-1-(tributylstannyl)methane with 4-substituted cyclohexanones in the presence of bis(oxazoline)s gave the products as a diastereomeric mixture. Each diastereomer obtained had high optical purity. The reaction of the α-seleno carbanion derived from the bis(phenylseleno) acetal also showed high enantioselectivity. The stereospecific elimination of the isolated diastereomers on treatment with methanesulfonyl chloride and triethylamine afforded axially chiral benzylidenecyclohexanes with high enantioselectivities up to 99% ee.
EFFICIENT OLEFINATION WITH α-ALKYL CYCLIC PHOSPHONAMIDES
Hanessian, Stephen,Bennani, Youssef L.,Leblanc, Yves
, p. 1411 - 1424 (2007/10/02)
A variety of acyclic and cyclic aldehydes and ketones can be converted into the corresponding alkylidene, benzylidene and methoxycarbonyl alkylidene derivatives by treatment with 1,3,2-diazaphospholidine-2-alkyl-1,3-dimethyl 2-oxides (α-alkyl cyclic phosphonamides) under mild conditions.This olefination method is particularly useful in the case of enolizable carbonyl compounds.
STUDIES IN ASYMMETRIC OLEFINATIONS - THE SYNTHESIS OF ENANTIOMERICALLY PURE ALLYLIDENE, ALKYLIDENE, AND BENZYLIDENE CYCLOHEXANES
Hanessian, Stephen,Beaudoin, Serge
, p. 7655 - 7658 (2007/10/02)
Treatment of alkyl cyclohexanones with topologically unique bicyclic phosphonamides derived from the C2 symmetrical (R,R)- and (S,S)-N,N'-dimethyl 1,2-trans-cyclohexane diamine leads to enantiomerically pure allylidene and benzylidene alkylcycl
Preparation, Alkylation Reactions, and Conformational Analysis of Esters of Phospholanic Acid. Preparation and Reactivity of (2S*,5S*)-1,2,5-Tribenzyl-1-oxophospholane
Polniaszek, Richard P.,Foster, Alvie L.
, p. 3137 - 3146 (2007/10/02)
Optimum conditions for the reaction of 1,4-butanediylmagnesium dibromide and alkyl phosphorodichloridates are described.The general geometric requirements of the cyclization reaction transition state are discussed.Alkylation reactions of phospholanate est
