1228363-07-2Relevant academic research and scientific papers
Azetidine-Derived Dinuclear Zinc-Catalyzed Asymmetric Conjugate Addition of Bioactive Heterocycles to β,γ-Unsaturated α-Keto esters
Liu, Shanshan,Xu, Zhi-Hua,Wang, Xi,Zhu, Hao-Ran,Wang, Min-Can
, p. 13881 - 13889 (2019/10/23)
A general AzePhenol dinuclear zinc catalytic system has been successfully developed and applied into the asymmetric Michael addition of 4-hydroxyl pyrones and 4-hydroxycoumarins to β,γ-unsaturated α-keto esters. Excellent yields (up to 99%) and high enantioselectivities (up to 94% ee) are obtained for a wide range of substrates under mild conditions in the absence of additives. This bimetallic catalytic approach represents a new and effective asymmetric synthetic protocol to access a variety of bioactive compounds with pharmacological interest. The possible mechanism is proposed to explain the origin of the asymmetric induction.
1,3-Diamine-Derived Bifunctional Organocatalyst Prepared from Camphor
Ri?ko, Sebastijan,Svete, Jurij,?tefane, Bogdan,Perdih, Andrej,Golobi?, Amalija,Meden, An?e,Gro?elj, Uro?
supporting information, p. 3786 - 3796 (2016/12/16)
Chiral 1,2-diamines are privileged structural motifs in organocatalysis, whereas efficient 1,3-diamine-derived organocatalysts are very rare. Herein we report a highly efficient camphor-1,3-diamine-derived squaramide organocatalyst. Its catalytic activity
Organocatalytic asymmetric conjugate addition of cyclic 1,3-dicarbonyl compounds to β,γ-unsaturated α-ketoesters
Wang, Jin-Jia,Lao, Jin-Hua,Hu, Zhi-Peng,Lu, Rui-Jiong,Nie, Shao-Zhen,Du, Quan-Sheng,Yan, Ming
experimental part, p. 229 - 243 (2010/12/24)
The conjugate addition of cyclic 1,3-dicarbonyl compounds to β;,γ-unsaturated α-keto-esters was studied using a series of chiral bifunctional organocatalysts. Takemoto's catalyst was found to be most efficient for this transformation. Excellent yields and good enantioselectivities were achieved for a variety of β,γ-unsaturated α-keto-esters and cyclic 1,3-dicarbonyl compounds. A bifunctional catalytic mechanism is proposed. The method provides a new asymmetric synthetic route for chiral courmarin derivatives. ARKAT USA, Inc.
Chiral squaramides as highly enantioselective catalysts for michael addition reacions of 4-hydroxycoumarins and 4-hydroxypyrone to β,γunsaturated α-keto esters
Xu, Dan-Qian,Wang, Yi-Feng,Zhang, Wei,Luo, Shu-Ping,Zhong, Ai-Guo,Xia, Ai-Bao,Xu, Zhen-Yuan
supporting information; experimental part, p. 4177 - 4180 (2010/09/15)
(Figure Presented) Distance brings forth beauty: The first highly enantioselective organocatalytic Michael addition of 4-hydroxycoumarins and the analogous 4-hydroxy-6methyl-2-pyrone to β,γ-unsaturated α-keto esters by using chiral squaramides as the orga
