55629-96-4Relevant academic research and scientific papers
Asymmetric Construction of α-Substituted β-Hydroxy Lactones via Ni Catalyzed Decarboxylative Addition Reaction
He, Lingchen,Ahmed, Ebrahim-Alkhalil M. A.,Liu, Hongxin,Hu, Xingen,Xiao, Hong-Ping,Li, Juan,Jiang, Jun
, p. 4825 - 4834 (2021/04/02)
We described a Ni-bidentate oxazoline catalyzed highly enantio- and diastereoselective decarboxylative aldol reaction of 2-oxotetrahydrofuran-3-carboxylic acid/2-oxochromane-3-carboxylic acid derivatives with different kinds of carbonyls. Under optimal reaction conditions, α-substituted β-hydroxy butyrolactones and dihydrocoumarins with an all-carbon quaternary stereocenter have been generated with high levels of functional-group compatibility. Furthermore, proficient transformations of products were also described, in which an aliphatic tertiary alcohol and a multi-substituted 1,4-diol were smoothly constructed through hydrogenation and ring-opening reaction, respectively.
Synthesis of Ketones by C?H Functionalization of Aldehydes with Boronic Acids under Transition-Metal-Free Conditions
Roscales, Silvia,Csáky, Aurelio G.
supporting information, p. 8728 - 8732 (2021/03/16)
A method for the synthesis of ketones from aldehydes and boronic acids via a transition-metal-free C?H functionalization reaction is reported. The method employs nitrosobenzene as a reagent to drive the simultaneous activation of the boronic acid as a boronate and the activation of the C?H bond of the aldehyde as an iminium species that triggers the key C?C bond-forming step via an intramolecular migration from boron to carbon. These findings constitute a practical, scalable, and operationally straightforward method for the synthesis of ketones.
Iodine mediated a simple strategy for the synthesis of β,γ-unsaturated-α-ketoesters and its application for the synthesis of 4,5-dihydropyrazole derivatives
Pommidi, Anil,Shaik, Asha Begum,Chatterjee, Anindita,Somarapu, Vijaya Laxmi
, p. 1545 - 1553 (2020/03/05)
Abstract: Novel and efficient method for the synthesis of a series of β,γ-unsaturated-α-ketoesters under mild conditions was developed. This one-step protocol was achieved by the reaction of electron-rich aromatic aldehydes and pyruvates in the presence o
Diversity-Oriented Synthesis of Spirocyclohexene Indane-1,3-diones and Coumarin-Fused Cyclopentanes via an Organobase-Controlled Cascade Reaction
Wang, Min,Tseng, Ping-Yao,Chi, Woei-Jye,Suresh, Sundaram,Edukondalu, Athukuri,Chen, Yi-Ru,Lin, Wenwei
, p. 3407 - 3415 (2020/07/16)
An organobase-controlled, divergent cascade reaction to construct spirocyclohexene indane-1,3-diones and coumarin-fused cyclopentanes is reported. The cascade reaction is triggered by the 1,6-addition of 3-homoacylcoumarins to the indanedione-derived acce
Direct Synthesis of β,γ-Unsaturated α-Keto Esters from Aldehydes and Pyruvates
Mansaray, John Kamanda,Sun, Jiarui,Huang, Shisheng,Yao, Weijun
supporting information, p. 809 - 813 (2019/04/25)
Herein, we describe two practical methods to synthesize β,γ-unsaturated α-keto esters directly from aldehydes and pyruvates promoted by BF 3 ?Et 2 O in the presence of Ac 2 O or by Ti(OEt) 4 under mild condition
Facile synthesis of substituted diaryl sulfones: Via a [3 + 3] benzannulation strategy
Tang, Xiang-Zheng,Tong, Lang,Liang, Hua-Ju,Liang, Jie,Zou, Yong,Zhang, Xue-Jing,Yan, Ming,Chan, Albert S. C.
supporting information, p. 3560 - 3563 (2018/05/26)
A base-mediated [3 + 3] benzannulation strategy for the conversion of 1,3-bis(sulfonyl)propenes and β,γ-unsaturated α-ketoesters to diaryl sulfones has been developed. This method provides facile, metal-free and efficient access to highly substituted diaryl sulfones in good to excellent yields. In addition, the sulfonyl group could be easily removed or converted to other functional groups via an organostannane intermediate.
Catalytic Generation of Donor-Acceptor Cyclopropanes under N-Heterocyclic Carbene Activation and their Stereoselective Reaction with Alkylideneoxindoles
Prieto, Liher,Sánchez-Díez, Eduardo,Uria, Uxue,Reyes, Efraím,Carrillo, Luisa,Vicario, Jose L.
, p. 1678 - 1683 (2017/05/22)
Formylcyclopropanes undergo activation in the presence of an N-heterocyclic carbene catalyst generating a donor-acceptor cyclopropane intermediate with the ability to undergo ring-opening followed by formal [4+2] cycloaddition with alkylideneoxindoles. This enables the direct enantio- and diastereoselective synthesis of tetrahydropyrano[2,3-b]indoles through the use of a chiral NHC catalyst. (Figure presented.).
α-Alkoxycarbonyl-α-hydroxy secondary amides from a carbamoylsilane and α-ketoesters
Li, Weidong,Han, Yuling,Chen, Jianxin
, p. 5813 - 5819 (2017/09/05)
The addition of N-methoxymethyl-N-organylcarbamoyl(trimethyl)silane to α-ketoesters in anhydrous toluene at 60 °C afforded α-alkoxycarbonyl-α-siloxy amides in high yields (75–96%). The methoxymethyl was used as an amino protecting group and could be easily converted into hydrogen atom by simple acid hydrolysis leading to α-alkoxycarbonyl-α- hydroxy secondary amides.
Synthesis of 1,2-Dicarbonyl-3-enes by Hydroacylation of 1-Alkynes with Glyoxal Derivatives Using Metal-Organic Framework Cu/MOF-74 as Heterogeneous Catalyst
Nguyen, Nguyen B.,Dang, Giao H.,Le, Dung T.,Truong, Thanh,Phan, Nam T. S.
, p. 361 - 369 (2016/04/26)
A crystalline copper-based metal-organic framework Cu/MOF-74 was synthesized, and used as an efficient heterogeneous catalyst for the synthesis of 1,2-dicarbonyl-3-enes by means of the hydroacylation of 1-alkynes with glyoxal derivatives in the presence o
A process for preparing (R) - 2-hydroxy-4-phenyl-butyric acid ethyl ester method (by machine translation)
-
, (2016/10/10)
The invention provides a process for preparing (R)? 2? Hydroxy? 4? Phenyl ethyl butyrate method of, in a cheap and easily obtained benzald and pyruvic acid as a raw material, by condensation, esterification, biological enzyme-catalyzed asymmetric reduction and double bond hydrogenated four-step efficient reaction, in order to eventually 82% overall yield of optically pure target product obtained (R)? HPBE. (by machine translation)
