1228363-42-5

Basic information

• Product Name: (R)-ethyl 4-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-4-phenylbutanoate
• Synonyms: (R)-ethyl 4-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-4-phenylbutanoate
• CAS NO: 1228363-42-5
• Molecular Weight: 330.337
• Mol File: 1228363-42-5.mol

Chemical Properties

• CAS DataBase Reference: (R)-ethyl 4-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-4-phenylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-ethyl 4-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-4-phenylbutanoate(1228363-42-5)
• EPA Substance Registry System: (R)-ethyl 4-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-4-phenylbutanoate(1228363-42-5)

Safety Data

• Hazardous Substances Data: 1228363-42-5(Hazardous Substances Data)

Upstream product

• 675-10-5 4-hydroxy-6-methyl-2-pyron 
• 55629-96-4 ethyl 4-phenyl-2-oxobut-3-enoate 

Relevant articles and documents

Azetidine-Derived Dinuclear Zinc-Catalyzed Asymmetric Conjugate Addition of Bioactive Heterocycles to β,γ-Unsaturated α-Keto esters

A general AzePhenol dinuclear zinc catalytic system has been successfully developed and applied into the asymmetric Michael addition of 4-hydroxyl pyrones and 4-hydroxycoumarins to β,γ-unsaturated α-keto esters. Excellent yields (up to 99%) and high enantioselectivities (up to 94% ee) are obtained for a wide range of substrates under mild conditions in the absence of additives. This bimetallic catalytic approach represents a new and effective asymmetric synthetic protocol to access a variety of bioactive compounds with pharmacological interest. The possible mechanism is proposed to explain the origin of the asymmetric induction.

Chiral squaramides as highly enantioselective catalysts for michael addition reacions of 4-hydroxycoumarins and 4-hydroxypyrone to β,γunsaturated α-keto esters

(Figure Presented) Distance brings forth beauty: The first highly enantioselective organocatalytic Michael addition of 4-hydroxycoumarins and the analogous 4-hydroxy-6methyl-2-pyrone to β,γ-unsaturated α-keto esters by using chiral squaramides as the orga