122846-56-4Relevant academic research and scientific papers
Palladium-catalyzed formal insertion of carbenoids into: N, O -aminals: Direct access to α-alkoxy-β-amino acid esters
Wang, Wenhui,Huang, Hanmin
, p. 3947 - 3950 (2019)
A new and efficient reaction has been developed to synthesize α-alkoxy-β-amino acid esters via palladium-catalyzed selective formal insertion of carbenoids into N,O-aminals under mild reaction conditions. A broad range of α-diazoesters with different substituents and various N,O-aminals were compatible with this protocol, affording the corresponding α-alkoxy-β-amino acid esters in good to excellent yields.
Synthesis of some 3-(1-azabicyclo[2.2.2]octyl) 3-amino-2-hydroxy-2-phenylpropionates: Profile of antimuscarinic efficacy and selectivity
Audia,McPherson,Weitzberg,Rzeszotarski,Sturm,Kachur,Abreu,Kaiser
, p. 307 - 310 (2007/10/02)
A series of 3-quinuclidinyl atrolactate [3-(1-azabicyclo[2.2.2]octyl) 2-hydroxy-2-phenylpropionate, QNA] derivatives in which the methyl group of the parent is substituted with a tertiary amino substituent was prepared and tested for antimuscarinic activi
1-AZABICYCLO[2.2.2]OCTAN-3-YL 2-ARYL-3-AZACYCLO-2-HYDROXYPROPIONATES AND THEIR QUATERNARY SALTS
-
, (2008/06/13)
Novel 1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts and their use as antimuscarinic agents having antisecretory activity selective for the gastrointestinal tract are disclosed. The compounds have the formula: STR1 wherein: X=H, halogen, lower alkyl, lower alkoxy, hydroxy, andR=morpholinyl, thiomorpholinyl, piperidinyl, 1,4-dioxa-8-azaspiro[4.5]decanyl, 4-(2,6-dimethylmorpholinyl), 4-ketopiperidinyl, 4-hydroxypiperidinyl, 4-substituted piperazinyl (wherein the substituent is lower alkyl, hydroxyalkyl, acetoxyalkyl, or acyl).Also disclosed are pharmaceutical compositions for treatment of irritable bowel syndrome and methods for using such compounds.
