1228508-75-5Relevant academic research and scientific papers
New opinions on the amidoalkylation of hydrophosphorylic compounds
Dmitriev, Maxim E.,Ragulin, Valery V.
supporting information; experimental part, p. 2613 - 2616 (2010/07/06)
A new and milder version of the procedure for the synthesis of N-protected α-aminoalkylphosphorylic compounds by reaction of alkyl carbamates, aldehydes and hydrophosphorylic compounds in acetic anhydride/acetyl chloride and a new mechanism for this type of reaction are described. The isolation, for the first time, of N,N′-benzylidene- and N,N′-alkylidenebiscarbamates as intermediates from the reaction medium and studies of the direct reaction of pre-obtained biscarbamates and hydrophosphorylic compounds in acetic anhydride are reported. A new version of the mechanism for this reaction which includes an Arbuzov-type reaction is proposed.
