1228935-05-4

Upstream product

• 137731-25-0 1-phenyl-4H-<1,2,4>-triazolo<4,3-a><1,5>benzodiazepin-5(6H)-one 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 174180-42-8 2-methyl-2-propanyl 3-(bromomethyl)-1H-indazole-1-carboxylate 

Downstream Products

• 1228935-21-4 tert-butyl 3-{[6-(2-tert-butoxy-2-oxoethyl)-4-methyl-5-oxo-1-phenyl-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-4-yl]methyl}-1H-indazole-1-carboxylate 
• 1374004-80-4 N-benzyl-2-[4-(1H-indazol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-2,3,6,10b-tetraazabenzo[e]azulen-6-yl]-N-isopropyl-acetamide 
• 1228934-56-2 (4S)-4-(1H-indazol-3-ylmethyl)-6-{2-[2-(2-methoxyethyl)piperidin-1-yl]-2-oxoethyl}-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one 
• 1228934-39-1 (4S)-6-[2-(2-benzylpiperidin-1-yl)2-oxoethyl]-4-(1H-indazol-3-ylmethyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one 
• 1373952-56-7 C₃₉H₃₇N₇O₂ 
• 1228934-52-8 (4S)-6-{2-[(2R)-2-(3,5-dimethylbenzyl)piperidin-1-yl]-2-oxoethyl}-4-(1H-indazol-3-ylmethyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one 
• 1228935-07-6 [(4S)-4-(1H-indazol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]acetic acid 
• 1228935-08-7 [(4R)-4-(1H-indazol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]acetic acid 
• 1228934-38-0 (4S)-6-(2-{2-[(4.6-dimethylpyridin-2-yl)methyl]piperidin-1-yl}-2-oxoethyl)-4-(1H-indazol-3-ylmethyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one 
• 1228934-54-0 6-{2-[2-(3.5-dimethylbenzyl)piperidin-1-yl]-2-oxoethyl}-4-(1H-indazol-3-ylmethyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one 
• 1228934-55-1 6-{2-[(2R)-2-(3,5-dimethylbenzyl)piperidin-1-yl]-2-oxoethyl}-4-(1H-indazol-3-ylmethyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one 
• 1228934-48-2 6-(2-{2-[(4,6-dimethylpyridin-2-yl)methyl]piperidin-1-yl}-2-oxoethyl)-4-(1H-indazol-3-ylmethyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one 
• 1228934-59-5 4-(1H-indazol-3-ylmethyl)-6-{2-[2-(3-methylbenzyl)piperidin-1-yl]-2-oxoethyl}-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one 
• 1228934-61-9 6-[2-(2-ethylpiperidin-1-yl)-2-oxoethyl]-4-(1H-indazol-3-ylmethyl)-4-methyl-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one 

Relevant academic research and scientific papers

Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists

New cholecystokinin-1 receptor (CCK1R) agonist 'triggers' were identified using iterative library synthesis. Structural activity relationship studies led to the discovery of compound 10e, a potent CCK1R agonist that demonstrated robust weight loss in a di

1,2,4 TRIAZOLO [4, 3 -A] [1,5] BENZODIAZEPIN-5 (6H) -ONES AS AGONISTS OF THE CHOLECYSTOKININ-1 RECEPTOR (CCK-IR)

This invention relates to CCK-1 R agonists of Formula (I) wherein R1-R5 and X are as defined in the specificiation, as well as pharmaceutical compositions containing the compounds and methods of use of the compounds and compositions. The compounds are useful in treating obesity, type 2 diabetes and associated diseases.