1374004-80-4Relevant academic research and scientific papers
Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists
Cameron, Kimberly O.,Beretta, Elena E.,Chen, Yue,Chu-Moyer, Margaret,Fernando, Dilinie,Gao, Hua,Kohrt, Jeffrey,Lavergne, Sophie,Jardine, Paul Da Silva,Guzman-Perez, Angel,Hoth, Christopher,Perry, David A.,Hadcock, John R.,Gautreau, Denise,Makowski, Michael,Perez, Sylvie,Polivkova, Jana,Rogers, Lucy,Scott, Dennis O.,Swick, Andrew G.,Thiede, Lucinda,Trebino, Catherine E.,Trilles, Richard V.,Wilmowski, Julie,Zhang, Yingxin
, p. 2943 - 2947 (2012/06/04)
New cholecystokinin-1 receptor (CCK1R) agonist 'triggers' were identified using iterative library synthesis. Structural activity relationship studies led to the discovery of compound 10e, a potent CCK1R agonist that demonstrated robust weight loss in a di
Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5- dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity
Elliott, Richard L.,Cameron, Kimberly O.,Chin, Janice E.,Bartlett, Jeremy A.,Beretta, Elena E.,Chen, Yue,Jardine, Paul Da Silva,Dubins, Jeffrey S.,Gillaspy, Melissa L.,Hargrove, Diane M.,Kalgutkar, Amit S.,Laflamme, Janet A.,Lame, Mary E.,Martin, Kelly A.,Maurer, Tristan S.,Nardone, Nancy A.,Oliver, Robert M.,Scott, Dennis O.,Sun, Dexue,Swick, Andrew G.,Trebino, Catherine E.,Zhang, Yingxin
supporting information; experimental part, p. 6797 - 6801 (2011/01/04)
We describe the design, synthesis, and structure-activity relationships of triazolobenzodiazepinone CCK1 receptor agonists. Analogs in this series demonstrate potent agonist activity as measured by in vitro and in vivo assays for CCK1 agonism. Our efforts
