1229-59-0

Basic information

• Product Name: 6-chloro-3-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
• Synonyms: 6-chloro-3-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
• CAS NO: 1229-59-0
• Molecular Formula: C₁₆H₁₁ClO₄
• Molecular Weight: 302.70914
• Mol File: 1229-59-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-chloro-3-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-3-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one(1229-59-0)
• EPA Substance Registry System: 6-chloro-3-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one(1229-59-0)

Safety Data

• Hazardous Substances Data: 1229-59-0(Hazardous Substances Data)

Usage

Chemical classification

2-phenyl-chromen-4-one derivative

Properties

Contains a chlorine atom at position 6 on the chromenone ring
Contains a hydroxyl group at position 3 on the chromenone ring
Contains a methoxy group at position 4 on the phenyl ring

Potential pharmacological activities

Antioxidant
Anti-inflammatory
Valuable target for medicinal chemistry research in the development of new drugs for various therapeutic applications

Upstream product

• 41255-30-5 4'-methylflavone 
• 126267-42-3 2'-hydroxy-5'-chloro-4-methoxychalcone 
• 1450-74-4 5-chloro-2-hydroxyacetophenone 
• 123-11-5 4-methoxy-benzaldehyde 
• 155723-53-8 2,4,4-Trimethoxy-2-p-tolyl-chroman-3-ol 
• 1226-09-1 (E)-1-(5-chloro-2-hydroxyphenyl)-3-(4-methoxyphenyl)-prop-2-en-1-one 

Downstream Products

• 131136-64-6 6-Chloro-3-hydroxy-2,3-dimethoxy-2-(4-methoxy-phenyl)-chroman-4-one 
• 1262841-07-5 6-chloro-2-(4'-methoxyphenyl)-3-{(thiophen-2-yl)methoxy}-4-oxo-4H-1-benzopyran 
• 1250865-51-0 6-chloro-3-methoxymethoxy-2-(4'-methoxyphenyl)-4-oxo-4H-1-benzopyran 
• 1062237-99-3 3-(allyloxy)-6-chloro-2-(4-methoxyphenyl)-4H-chromen-4-one 
• 111391-79-8 6-chloro-3-methoxy-2-(4'-methoxyphenyl)-4-oxo-4H-1-benzopyran 

Relevant articles and documents

Absorption and fluorescent studies of 3-hydroxychromones

The synthesis and spectral studies of variously substituted 3-hydroxychromones have been carried out. A key relationship between the structural motif of synthesized 3-hydroxychromones (3-HCs) and their fluorescent properties was found. The chromones substituted with electron-donating group at 4′-position expressed the red shift of the N and T band and also exhibited the increased fluorescent intensity ratio while the chromones with electron-withdrawing group showed the blue shift of the N and T band. Therefore, these 3-HCs may behave as the possible fluorescent probes.

C-3 Hydroxylation of flavones using hypervalent iodine oxidation

Hypervalent iodine oxidation of several flavones (1b-g) with iodobenzene diacetate in methanolic potassium hydroxide, followed by acid hydrolysis of the resultant 3-hydroxy-2-methoxyflavonones dimethylacetals (2b-g), offers a general method for 3-hydroxyflavones (3b-g).