1229236-81-0 Usage
Molecular structure
The compound has a long and specific molecular structure, which includes a chloro, fluorobenzoyl, and imidazo group, along with isoindoline and dione functional groups.
Chloro group
The presence of a chlorine atom bonded to a carbon atom in the 6-position of the imidazo[1,2-b]pyridazine ring.
Fluorobenzoyl group
A benzoyl group (C6H5CO-) with a fluorine atom attached to the 2-position of the benzene ring.
Imidazo group
A 5-membered heterocyclic ring system containing nitrogen atoms, which is part of the imidazo[1,2-b]pyridazine core structure.
Isoindoline group
A fused bicyclic structure consisting of a 6-membered benzene ring and a 5-membered nitrogen-containing ring (isoindoline core).
Dione functional group
Two carbonyl groups (C=O) separated by a single carbon atom, which is part of the 1,3-dione structure.
Potential applications
The compound may have potential biological or pharmaceutical applications due to its unique structure.
Further research
Additional studies would be needed to determine the specific properties and uses of this compound.
Check Digit Verification of cas no
The CAS Registry Mumber 1229236-81-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,9,2,3 and 6 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1229236-81:
(9*1)+(8*2)+(7*2)+(6*9)+(5*2)+(4*3)+(3*6)+(2*8)+(1*1)=150
150 % 10 = 0
So 1229236-81-0 is a valid CAS Registry Number.
1229236-81-0Relevant articles and documents
Development and a practical synthesis of the JAK2 inhibitor LY2784544
Mitchell, David,Cole, Kevin P.,Pollock, Patrick M.,Coppert, David M.,Burkholder, Timothy P.,Clayton, Joshua R.
, p. 70 - 81 (2012/05/31)
The route selection and process research and development of a practical synthesis for JAK2 inhibitor LY2784544 is described. The first-generation synthesis route, similar to that used in discovery for derivatization of a benzylic amine moiety, was 14 overall steps and possessed several steps that required extensive development for large-scale production. Route selection considerations led to a modified synthesis that utilized a novel vanadium-catalyzed carbon-carbon bond-forming arylation reaction for incorporation of the key benzylic morpholine moiety. A protecting group used to mask an amino pyrazole unit was modified from PMB to tert-butyl, resulting in a dramatic reduction in the overall length of the route. These two major changes resulted in an eight-step synthesis, which was six steps shorter than the first-generation synthesis. In the pilot plant, the new synthesis was scaled to produce >100 kg of LY2784544 in high yield and purity under GMP conditions. The overall development including the vanadium-catalyzed C-C bond-forming methodology, a ketone reductive deoxygenation, and a palladium-catalyzed amination is described.
