1229426-30-5

Basic information

• Product Name: ethyl 3-(1-methyl-1H-imidazol-2-yl)-3-oxopropanoate
• Synonyms: ethyl 3-(1-methyl-1H-imidazol-2-yl)-3-oxopropanoate
• CAS NO: 1229426-30-5
• Molecular Weight: 196.206
• Mol File: 1229426-30-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: ethyl 3-(1-methyl-1H-imidazol-2-yl)-3-oxopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(1-methyl-1H-imidazol-2-yl)-3-oxopropanoate(1229426-30-5)
• EPA Substance Registry System: ethyl 3-(1-methyl-1H-imidazol-2-yl)-3-oxopropanoate(1229426-30-5)

Safety Data

• Hazardous Substances Data: 1229426-30-5(Hazardous Substances Data)

Upstream product

• 30148-21-1 ethyl 1-methyl-1H-imidazole-2-carboxylate 
• 141-78-6 ethyl acetate 
• 616-47-7 1-methyl-1H-imidazole 
• 1260897-73-1 ethyl 3-(methoxy(methyl)amino)-3-oxopropanoate 
• 6148-64-7 ethyl potassium malonate 
• 85692-37-1 1-(1-methyl-1H-imidazol-2-yl)ethan-1-one 
• 105-58-8 Diethyl carbonate 

Relevant articles and documents

CYCLIC AMINE DERIVATIVE AS AGENT FOR PROMOTING ADVILLIN FUNCTION, AND NOVEL CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

An object of the present invention is to provide an agent for promoting advillin function that comprises a low molecular weight compound, and is useful for treatment of axonal injury. The present invention provides an agent for promoting advillin function, comprising a cyclic amine derivative typically represented by the following chemical formula, or a pharmacologically acceptable salt thereof as an active ingredient.

CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

An object of the present invention is to provide a compound exerting an analgesic effect against pain, in particular, neuropathic pain and/or fibromyalgia syndrome. The present invention provides a cyclic amine derivative represented by the following general formula, or a pharmacologically acceptable salt thereof.

Simple, fast and efficient synthesis of β-keto esters from the esters of heteroaryl compounds, its antimicrobial study and cytotoxicity towards various cancer cell lines

A series of β-keto esters were synthesized from heteroaryl esters and ethyl acetate using LiHMDS as base at -50 to -30 °C. The increase in yields of cross condensed product were observed and the percentage of self condensed product was reduced drastically by applying the suitable base (LiHMDS), solvent and the minimum amount of ethyl acetate. All these β-keto esters were characterized using 1H NMR, 13C NMR and mass spectral data. A plausible mechanism is also depicted to prove the formation of trans-esterified products. All the synthesized compounds were subjected to test for their cytotoxicity towards various cancer cell lines and also tested for their antimicrobial activity towards various bacterial and fungal strains and some of them were found to have promising activity.