1229442-68-5

Basic information

• Product Name: ethyl 3-bromo-5-ethoxybenzoate
• Synonyms: ethyl 3-bromo-5-ethoxybenzoate
• CAS NO: 1229442-68-5
• Molecular Weight: 273.126
• Mol File: 1229442-68-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: ethyl 3-bromo-5-ethoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-bromo-5-ethoxybenzoate(1229442-68-5)
• EPA Substance Registry System: ethyl 3-bromo-5-ethoxybenzoate(1229442-68-5)

Safety Data

• Hazardous Substances Data: 1229442-68-5(Hazardous Substances Data)

Upstream product

• 42237-85-4 3-amino-5-bromobenzoic acid 
• 6307-83-1 3-bromo-5-nitro-benzoic acid 
• 121-92-6 3-nitrobenzoic acid 
• 74-96-4 ethyl bromide 
• 140472-69-1 3-bromo-5-hydroxy-benzoic acid 
• 75-03-6 ethyl iodide 

Downstream Products

• 1333896-51-7 ethyl 3-(3,5-dimethylisoxazol-4-yl)-5-ethoxybenzoate 
• 1333896-52-8 3-(3,5-dimethylisoxazol-4-yl)-5-ethoxybenzoic acid 
• 1333896-50-6 1-(3-bromo-5-ethoxyphenyl)ethanone 
• 1180016-49-2 3-bromo-5-ethoxy-N-methoxy-N-methylbenzamide 
• 1333896-53-9 1-(3-(3,5-dimethylisoxazol-4-yl)-5-ethoxyphenyl)ethanone 
• 1333896-54-0 (RS)-1-(3-(3,5-dimethylisoxazol-4-yl)-5-ethoxyphenyl)ethanol 
• 855198-27-5 3-bromo-5-ethoxybenzoic acid 
• 1229442-69-6 ethyl 3-ethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 
• 1229441-31-9 N-cyclopropyl-3'-(5-(3-(3,5-dichloropyridin-4-yl)ureido)-1-ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-ethoxy-[1,1'-biphenyl]-3-carboxamide 

Relevant articles and documents

HYDROXY FORMAMIDE DERIVATIVES AND THEIR USE

Disclosed are compounds having the formula: (I) wherein R1, R2 and R3 are as defined herein, and methods of making and using the same, including use as inhibitors of BMP1, TLL1 and/or TLL2 and in treatment of diseases associated with BMP1, TLL1 and/or TLL2 activity.

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands

Histone-lysine acetylation is a vital chromatin post-translational modification involved in the epigenetic regulation of gene transcription. Bromodomains bind acetylated lysines, acting as readers of the histone-acetylation code. Competitive inhibitors of this interaction have antiproliferative and anti-inflammatory properties. With 57 distinct bromodomains known, the discovery of subtype-selective inhibitors of the histone-bromodomain interaction is of great importance. We have identified the 3,5-dimethylisoxazole moiety as a novel acetyl-lysine bioisostere, which displaces acetylated histone-mimicking peptides from bromodomains. Using X-ray crystallographic analysis, we have determined the interactions responsible for the activity and selectivity of 4-substituted 3,5-dimethylisoxazoles against a selection of phylogenetically diverse bromodomains. By exploiting these interactions, we have developed compound 4d, which has IC50 values of 5 μM for the bromodomain-containing proteins BRD2(1) and BRD4(1). These compounds are promising leads for the further development of selective probes for the bromodomain and extra C-terminal domain (BET) family and CREBBP bromodomains.

SUBSTITUTED SPIROCYCLIC AMINES USEFUL AS ANTIDIABETIC COMPOUNDS

Substituted spirocyclic amines of structural formula I are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, metabolic syndrome, depression, and anxiety.