1229611-42-0

Basic information

• Product Name: 4-(4-(3-(4-fluorophenyl)thioureido)phenoxy)-N-methylpicolinamide
• CAS NO: 1229611-42-0
• Molecular Weight: 396.445
• Mol File: 1229611-42-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-(3-(4-fluorophenyl)thioureido)phenoxy)-N-methylpicolinamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-(3-(4-fluorophenyl)thioureido)phenoxy)-N-methylpicolinamide(1229611-42-0)
• EPA Substance Registry System: 4-(4-(3-(4-fluorophenyl)thioureido)phenoxy)-N-methylpicolinamide(1229611-42-0)

Safety Data

• Hazardous Substances Data: 1229611-42-0(Hazardous Substances Data)

Upstream product

• 98-98-6 2-Picolinic acid 
• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 
• 123-30-8 4-amino-phenol 
• 371-40-4 4-fluoroaniline 
• 220000-87-3 4-chloro-N-methylpicolinamide 

Relevant articles and documents

Design, synthesis and biological activities of thiourea containing sorafenib analogs as antitumor agents

A novel series of diaryl thiourea containing sorafenib derivatives 9a-t was designed and synthesized. The structures of all the newly synthesized compounds were determined by 1H NMR, 13C NMR and HRMS. Their antiproliferative activities against HCT116 and MDA-MB-231 cell lines, and their inhibitory activities against the phosphorylation of VEGFR were evaluated and described. Some of the compounds showed significant activities against both cell lines and VEGFR. Compounds 9g, 9m, 9o and 9p demonstrated competitive antiproliferative activities to sorafenib, the reference standard, while compounds 9d, 9m, and 9p showed significant inhibitory activities against the phosphorylation of VEGFR.