122969-11-3

Basic information

• Product Name: (3RS,1'RS)-1-methyl-3-(1'-methyl-3'-oxo-3'-phenylpropyl)2-pyrrolidinone
• CAS NO: 122969-11-3
• Molecular Weight: 245.321
• Mol File: 122969-11-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3RS,1'RS)-1-methyl-3-(1'-methyl-3'-oxo-3'-phenylpropyl)2-pyrrolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (3RS,1'RS)-1-methyl-3-(1'-methyl-3'-oxo-3'-phenylpropyl)2-pyrrolidinone(122969-11-3)
• EPA Substance Registry System: (3RS,1'RS)-1-methyl-3-(1'-methyl-3'-oxo-3'-phenylpropyl)2-pyrrolidinone(122969-11-3)

Safety Data

• Hazardous Substances Data: 122969-11-3(Hazardous Substances Data)

Upstream product

• 872-50-4 1-methyl-pyrrolidin-2-one 
• 35660-91-4 (E)-1-phenyl-2-buten-1-one 
• 98-86-2 acetophenone 
• 13505-39-0 3-hydroxy-1-phenyl-butan-1-one 

Downstream Products

• 122969-53-3 (3RS,1'SR)-3-(3'-(hydroxyimino)-1'-methyl-3'-phenylpropyl)-1-methyl-2-pyrrolidinone 

Relevant articles and documents

Stereochemistry of the Michael Addition of N,N-Disubstituted Amide and Thioamide Enolates to α,β-Unsaturated Ketones

A systematic study of the regio- and diastereoselectivity of the kinetic Michael addition of amide and thioamide enolates to a series of α,β-unsaturated ketones has been carried out.Factors that influence the diastereo- and regiochemical outcome of the reaction include the substitution pattern of the enone and enolate, the enolate counterion, and the solvent.Numerous examples of high selectivity have been discovered.In a number of examples, either the syn or the anti addition products can be obtained by varying the nature of the solvent, donor atom, and/or counterion.These results have correlated in terms of a coherent transition-state model.