122970-32-5Relevant academic research and scientific papers
Nucleic acid related compounds. 114. Synthesis of 2,6-(disubstituted)purine 2′,3′-dideoxynucleosides and selected cytotoxic, anti-hepatitis B, and adenosine deaminase substrate activities
Robins, Morris J.,Wilson, John S.,Madej, Danuta,Tyrrell, D. Lorne J.,Gati, Wendy P.,Lindmark,Wnuk, Stanislaw F.
, p. 1297 - 1306 (2007/10/03)
Selected 2,6-(disubstituted)purine 2′,3′-didehydro-2′,3′-dideoxynucleosides and 2′,3′-dideoxynucleosides were prepared and evaluated. Treatment of 5′-protected ribonucleosides with phenoxythiocarbonyl chloride and 4-(dimethylamino)pyridine, or under Schot
Novel, Stable Congeners of the Antiretroviral Compound 2',3'-Dideoxyadenosine
Nair, Vasu,Buenger, Greg S.
, p. 8502 - 8504 (2007/10/02)
Novel congeners of the antiretroviral compound 2',3'-dideoxyadenosine (ddA) have been synthesized through metal-mediated and photochemical conversions as the key steps.These compounds are inherently more stable than ddA with respect to both glycosidic bond cleavage and deamination by adenosine deaminase.
