122980-96-5Relevant articles and documents
Condensation of Reformatsky Reagents with Acetals in the Presence of TiCl4: a Novel Entry to Enantiomerically-enriched β-Hydroxy-esters
Basile, Tiziana,Tagliavini, Emilio,Trombini, Claudio,Umani-Ronchi, Achille
, p. 596 - 597 (1989)
3-Alkoxy esters are prepared in high yield from the reaction of ethyl zinc-bromoacetate and acetals in the presence of TiCl4 under very mild conditions; using chiral acetals the corresponding 3-hydroxy esters have been obtained in fair enantiomeric excess.