Condensation of Reformatsky Reagents with Acetals in the Presence of TiCl4: a Novel Entry to Enantiomerically-enriched β-Hydroxy-esters

DOI: 10.1039/c39890000596

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 596 - 597 (1989)

Update date:2022-07-29

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Authors:

Basile, Tiziana

Tagliavini, Emilio

Trombini, Claudio

Umani-Ronchi, Achille

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Article abstract of DOI:10.1039/c39890000596

3-Alkoxy esters are prepared in high yield from the reaction of ethyl zinc-bromoacetate and acetals in the presence of TiCl4 under very mild conditions; using chiral acetals the corresponding 3-hydroxy esters have been obtained in fair enantiomeric excess.

Full text of DOI:10.1039/c39890000596

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