Condensation of Reformatsky Reagents with Acetals in the Presence of TiCl4: a Novel Entry to Enantiomerically-enriched β-Hydroxy-esters

DOI: 10.1039/c39890000596

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 596 - 597 (1989)

Update date:2022-07-29

Topics:

Authors:

Basile, Tiziana

Tagliavini, Emilio

Trombini, Claudio

Umani-Ronchi, Achille

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1039/c39890000596

3-Alkoxy esters are prepared in high yield from the reaction of ethyl zinc-bromoacetate and acetals in the presence of TiCl4 under very mild conditions; using chiral acetals the corresponding 3-hydroxy esters have been obtained in fair enantiomeric excess.

Full text of DOI:10.1039/c39890000596

View Article Online / Journal Homepage / Table of Contents for this issue

View Article Online

Products guided by the article

Product name:(R)-3-((S)-3-Hydroxy-1-methyl-propoxy)-3-phenyl-propionic acid ethyl ester

Cas No:122980-96-5

R&D Labs maybe for 122980-96-5

Tocopharm Co., Ltd.

Contact:+86-021-6989-5597

Address:No.80 Yichuan Rd., Putuo District,Shanghai,P.R.China
Jiangsu Zhenfang Chemical CO.,LTD.(Suzhou Zhenfang Chemical Factory)

Contact:+86-512-69598882

Address:Room1201, Jiayuan Road No.1018, Xiangcheng District, Suzhou, China
Jiangxi Hessence Chemicals Co., Ltd.

Contact:+86 796 3511924

Address:Chengxi Industrial Park, Jishui County, Jiangxi Province 331600 China.
JIAXING SUNS INTERNATIONAL TRADE CO LTD

Contact:18367306858

Address:No.123,Huixin Avenue,Huimin Dist
Hebei Fulong Import & Export Co., Ltd.

Contact:86-311-87795661

Address:15A19 Zhongyuan Building,368 Youyi North Street,Shijiazhuang 050070,China

Relevant to this article

HETEROCUMULENES IN HETEROARYLATION

Doi:10.1007/BF00472282
(1991)
Highly efficient Rh^I-catalyzed asymmetric hydrogenation of β-amino acrylonitriles

Doi:10.1002/chem.201000325
(2010)
Diketene as an alternative substrate for a new Biginelli-like multicomponent reaction: one-pot synthesis of 5-carboxamide substituted 3,4-dihydropyrimidine-2(1H)ones

Doi:10.1016/j.tet.2010.04.028
(2010)
1,8-Cyclotetradecadiyne complexes of molybdenum(II) and tungsten(II)

Doi:10.1016/0022-328X(88)83027-4
(1988)
Catalytic asymmetric 1,3-dipolar cycloaddition of α-iminonitriles

Doi:10.1002/chem.200903443
(2010)
Synthesis and biological activity of N⁴-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents

Doi:10.1016/j.bmc.2010.03.052
(2010)

Article Doi