123-85-3Relevant articles and documents
4-Homoisotwistane derivatives
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, (2008/06/13)
A new class of 4-homoisotwistane derivatives of the formula, STR1 wherein R1 is a hydrogen atom or a C1 -C3 alkyl group, and R2 is an alkyl group, a phenyl group which may be either unsubstituted or substituted with a C1 -C3 alkyl, C1 -C3 alkoxy, nitro group or a halogen atom (hereinafter referred to as "an optionally substituted phenyl group"), a group of the formula, --A--OH in which A is a C1 -C3 alkylene group; a group of the formula, --A--B in which A is as defined as above and B is a halogen atom, or a group of the formula, STR2 in which A is as defined above and R3 and R4 are independently a hydrogen atom or a C1 -C3 alkyl group or R3 and R4 may, when taken together with the adjacent nitrogen atom to which R3 and R4 are linked, form pyrrolidine, piperidine, morpholine, phthalimide or piperazine, which have been found to possess potent antiviral activity, are prepared, for example by reacting a compound of the formula, STR3 wherein R1 is as defined above and X is halogen, with a compound of the formula, wherein R5 has the same meanings as R2 with the exception of the group of the formula --A--B wherein A and B are as defined above and Y is alkali metal.