123003-83-8Relevant academic research and scientific papers
β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand
O'Boyle, Niamh M.,Pollock, Jade K.,Carr, Miriam,Knox, Andrew J. S.,Nathwani, Seema M.,Wang, Shu,Caboni, Laura,Zisterer, Daniela M.,Meegan, Mary J.
, p. 9370 - 9382 (2015/01/09)
Twelve novel β-lactams were synthesized and their antiproliferative effects and binding affinity for the predominant isoforms of the estrogen receptor (ER), ERα and ERβ, were determined. β-Lactams 23 and 26 had the strongest binding affinities for ERα (IC
Chemoselective synthesis of β-amino ester or β-lactam via sonochemical reformatsky reaction
Lee, Adam Shih-Yuan,Chang, Yu-Ting,Su, Feng-Yi
, p. 290 - 294 (2014/05/06)
A series of β-amino esters were synthesized by the reaction of N-tosyl aldimine or N-hydroxy aldimine with bromoacetate by sonochemical Reformatsky reaction. The β-N-hydroxyamino ester was obtained and the formed sensitive hydroxylamino functionality was
The Reformatsky Type Reaction of Gilman and Speeter in the Preparation of Valuable β-Lactams in Carbapenem Synthesis: Scope and Synthetic Utility
Palomo, Claudio,Cossio, Fernando P.,Arrieta, Ana,Odriozola, Jose M.,Oiarbide, Mikel,Ontoria, Jesus M.
, p. 5736 - 5745 (2007/10/02)
The preparation of apppropriately substituted 3-alkyl β-lactams from the Reformatsky type reaction of Gilman and Speeter is described.Treatment of Schiff bases derived from α-methylcinnamaldehyde and amines with ethyl α-bromobutyrate or ethyl α-bromoisova
