123016-86-4

Upstream product

• 100-52-7 benzaldehyde 
• 171414-56-5 Bis(trimethylsilyl)methyl isocyanate 
• 171414-55-4 <imino>triphenylphosphorane 
• 5926-35-2 chlorobis(trimethylsilyl)methane 
• 134340-01-5 bis(trimethylsilyl)methyl azide 

Downstream Products

• 198022-17-2 (3S,4R)-1-[bis(trimethylsilyl)methyl]-4-phenyl-3-[(4S,5R)-4,5-diphenyl-2-oxo-oxazolidin-3-yl]-azetidin-2-one 
• 143360-55-8 (E)-5-Phenyl-pent-2-enoic acid benzyl-(bis-trimethylsilanyl-methyl)-amide 
• 143360-54-7 (E)-N-Benzyl-N-(bis-trimethylsilanyl-methyl)-3-(4-methoxy-phenyl)-acrylamide 
• 1026458-49-0 (E)-N-Benzyl-N-(bis-trimethylsilanyl-methyl)-2-methyl-3-phenyl-acrylamide 
• 143360-53-6 N-Benzyl-N-(bis-trimethylsilanyl-methyl)-3-phenyl-propionamide 
• 143360-64-9 N-Benzyl-N-((1E,3E)-3-methyl-4-phenyl-buta-1,3-dienyl)-benzamide 
• 143360-37-6 N-Benzyl-N-(bis-trimethylsilanyl-methyl)-benzamide 
• 143360-36-5 N-Benzyl-N-(bis-trimethylsilanyl-methyl)-2-methoxy-acetamide 
• 143360-63-8 N-Benzyl-N-((E)-3,3-dimethyl-but-1-enyl)-benzamide 
• 143360-61-6 N-Benzyl-N-[(E)-2-(4-methoxy-phenyl)-vinyl]-acetamide 
• 143360-62-7 N-Benzyl-N-((E)-3,3-dimethyl-but-1-enyl)-2-methoxy-acetamide 
• 143360-56-9 (E)-But-2-enoic acid benzyl-(bis-trimethylsilanyl-methyl)-amide 
• 143360-52-5 N-Benzyl-N-(bis-trimethylsilanyl-methyl)-propionamide 
• 143360-35-4 N-Benzyl-N-(bis-trimethylsilanyl-methyl)-acetamide 

Relevant academic research and scientific papers

Synthesis and Reactivity of N-heterocumulenes

A number of N-heterocumulenes bearing the (Me3Si)2CH (BSM) substituent adjacent to the terminal nitrogen atom of the heterocumulene function, namely BSM-N=C=O (2), BSM-N=C=S (3), BSM-N=C=NR (4: R = BSM; 5: R = C6H5), BSM-N=C=CR1R2 (9a: R1 = R2 = C6H5; 9b: R1 = H, R2 = SiMe3; 10: R1 = R2 = CH3; 12: R1 = H; R2 = CH3), and BSM-N=S=O (14), have been synthesized.The synthetic utility of the BSM-N-substituted heterocumulenes has been explored through the creation of a carbanion center at the α position relative to nitrogen.In particular, the following reactions have been studied: (i) the nucleophilic addition of MeLi to compounds 2 and 5, (ii) the MeLi-induced deprotonation of ketene imines 9a,b (this investigation includes the study of the regiochemical output of the addition of electrophiles (H2O, MeI, Me2CHI) to the resulting 1,3-dipoles; and (iii) the TBAF-induced desilylation of compounds 2 and 9a followed by reaction with benzaldehyde.

Fluoride Ion Mediated Peterson Alkenation of N-amido Derivatives with Carbonyl Compounds: A Short General Route to Enamides and 1,2-Dihydroisoquinolines

A straighforward general access to diversely substituted acyclic or cyclic enamides and dienamides is accomplished by using a fluoride induced Peterson olefination of carbonyl compounds and enolizable amides derived from C,C-bis(trimethylsilyl)methylamine