123023-79-0

Upstream product

• 115-22-0 3-Hydroxy-3-methyl-2-butanone 
• 123-11-5 4-methoxy-benzaldehyde 
• 1174672-36-6 1-(4-methoxyphenyl)-4-methylpent-2-yne-1,4-diol 
• 115-19-5 2-methyl-but-3-yn-2-ol 
• 100-09-4 4-methoxybenzoic acid 
• 81791-30-2 (E)-4-hydroxy-1-(4-methoxyphenyl)-4-methylpent-1-en-3-one 
• 125349-00-0 2-hydroxy-5-(4-methoxyphenyl)-2-methylpent-4-yn-3-one 
• 3717-21-3 (E)-4-methoxybenzaldoxime 

Downstream Products

• 1202376-46-2 4-bromo-5-(4-methoxyphenyl)-2,2-dimethylfuran-3(2H)-one 
• 1202368-40-8 5-(4-methoxyphenyl)-2,2-dimethyl-4-(4-(quinolin-2-ylmethoxy)phenyl)furan-3(2H)-one 
• 1202375-49-2 5-(4-hydroxyphenyl)-2,2-dimethyl-4-(4-(quinolin-2-ylmethoxy)phenyl)furan-3(2H)-one 

Relevant academic research and scientific papers

Cationic gold(I)-catalyzed intramolecular cyclization of γ-hydroxyalkynones into 3(2H)-furanones

"Chemical Equation Presented" The combination of (p-CF 3C6H4)3PAuCl and AgOTf generates a powerful catalyst for the intramolecular cyclizations of readily available y-hydroxyalkynones un-der mild conditions. The

1, 2 DISUBSTITUTED HETEROCYCLIC COMPOUNDS

1,2-disubstituted heterocyclic compounds which are inhibitors of phosphodiesterase 10 are described. Also described are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of mammals, including human(s) for central nervous system (CNS) disorders and other disorders which may affect CNS function. Among the disorders which may be treated are neurological, neurodegenerative and psychiatric disorders including, but not limited to, those associated with cognitive deficits or schizophrenic symptoms.

Palladium-catalyzed oxidative cyclizations: Synthesis of dihydropyranones and furanones

A boron-mediated syn- and anti-stereoselective aldol reaction giving rise to various β-hydroxyenones was coupled to a Pd(II)-mediated oxidative cyclization to give 2,3,6-trisubstituted syn- and antidihydropyranones in good yields. The Pd(I

Preparation of furans by palladium-catalyzed reaction of acylchromates and propargylic tosylates

Substituted furans are prepared by the palladium-catalyzed reaction of propargylic tosylates with acylchromates. The reaction is initiated by the oxidative additiion of propagylic tosylates to palladium(O) complexes to give 1,2-propadienylpalladium(II) co

Triphenylphosphonioacetylide: A species isoelectronic with isocyanides

Stabilized only by triphenylphosphane, the title compound 1 was synthesized and investigated theoretically (the HOMO of 1 is depicted on the right). Both calculations and experimental NMR spectra show that no Lewis structure can describe the geometry and

Synthesis and antiulcer activity of novel 5-(2-ethenyl substituted)-3(2H)- furanones

In order to investigate new antiulcer agents, spizofurone 1 (AG-629) was fragmented and reassembled to generate 5-phenyl-2,2-dimethyl-3(2H)-furanone (bullatenone, 2). Because of the antiulcer activity of 2,5-phenyl-substituted 2,2-dimethyl-3(2H)-furanones (3-6) were made and shown to have poor activity. Insertion of an ethenyl link between the furanone and phenyl rings gave 5-(2- phenylethenyl)-2,2-dimethyl-3(2H)-furanone (7). This compound had better activity than 2. Compounds 8-41 were synthesized to evaluate the SAR in 5-(2- ethenyl substituted)-3(2H)-furanones. Electron-withdrawing substituents on the aromatic ring (8, 10, 19, and 20) gave 2-3-fold higher activity. Further increases in the activity were found when the phenyl ring was replaced by heterocyclic nuclei. Compounds that contained a thiophene (29), pyridine (24- 26), or quinoline ring (32) had the best activity. Replacement of the methyl group on the furanone ring with a phenyl (34) or p-fluorophenyl (40) substituent in the 2-pyridine series gave compounds with activity that ranked with the best obtained in this study. The best compounds from the above SAR studies were evaluated in the ethanol-necrosis model for duration of cytoprotection action. Compounds 19, 24, and 29, which had the best duration of action, were tested with AG-629 in the acidified aspirin and indomethacin- induced lesion models. Only compound 24 had equivalent activity with AG-629 in both models.

Ring Closure to Ynone Systems: 5- and 6-endo- and -exo-dig Modes

The rates of cyclisation of 2-hydroxy-2-methyl-5-arylpent-4-yn-3-ones in trifluoroacetic acid are reported.An approximate ρ value of -4.0 (using ?+) and a kinetic isotope effect KTFA/KTFA-d' of 4.2 are observed, which suggest that the reaction proceeds via rate-limiting triple-bond protonation and does not entail carbonyl protonation along the reaction co-ordinate.The base-catalysed ring closure occurs via the vinilyc carbanion.A similar mechanistic picture appears to be involved in the cyclisation of 1-(2-hydroxyphenyl)-3-arylprop-2-yn-1-ones which yield a mixture of flavone and aurone in base, whilst in acid only the flavone is observed.In contrast with recent theoretical studies, the base-catalysed results appear to conform to Baldwin's original proposal of acute-angle approach of a nucleophile to a triple bond.