123043-91-4

Upstream product

• 123043-88-9 5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione 
• 74-88-4 methyl iodide 
• 100-52-7 benzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 108958-81-2 Ethyl 1,6-dimethyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 144460-13-9 3-ethoxycarbonyl-7-(2,4-dichlorophenoxy)-1,2-dimethyl-4-phenyl-6-methylthio-1,5-diazabicyclo<4.2.0>oct-2-en-8-one 
• 144460-17-3 3-ethoxycarbonyl-7-(2,4-dichlorophenoxy)-1,2-dimethyl-4-phenyl-1,5-diazabicyclo<4.2.0>oct-2-en-8-one 
• 144460-09-3 3-ethoxycarbonyl-1,2-dimethyl-4-phenyl-7-phenoxy-6-methylthio-1,5-diazabicyclo<4.2.0>oct-2-en-8-one 
• 123044-27-9 ethyl 1,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate 

Relevant academic research and scientific papers

Synthesis and Reactions of "Biginelli-Compounds". Part I

Various reactions of 2-oxo (or thioxo)-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid derivatives (Biginelli-compounds) were investigated.The site of methylation and acylation on 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester 1a and its 2-oxo derivative 9a was studied.The synthesis of pyrimidothiazines and thiazolopyrimidines was accomplished by condensation of 1a with 1,3- and 1,2-dielectrophiles.A Dimroth-like rearrangement yielding 6H-1,3-thiazines can be observed when 1a was treated with dimethylformamide and phosphorus oxychloride.The formation of indenopyrimidines can be achieved by intramolecular Friedl-Crafts acylation of 9a and 13, respectively.Finally a route for the preparation of 4,6-disubstituted-pyrimidine-5-carbonitriles is presented, starting with Biginelli-compound 25.

Syntheses of 2,3-Dihydro-5H-thiazolopyrimidines and Tetrasubstituted Dihydropyrimidine Derivatives as Possible Anthelmintic Agents

The hitherto unreported ring closure reaction of 5-ethoxycarbonyl-6-methyl-4-substitutedphenyl-3,4-dihydropyrimidine-2-thione with monochloroacetic acid in the presence of BF3-etherate is described.The reaction appears to have a general applicability and