123044-27-9

Upstream product

• 141-97-9 ethyl acetoacetate 
• 100-52-7 benzaldehyde 
• 598-50-5 N-Methylurea 
• 123043-91-4 1,6-dimethyl-2-methylthio-4-phenyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester 
• 71814-29-4 3-(N'-methyl-ureido)-crotonic acid ethyl ester 
• 67-56-1 methanol 
• 123237-03-6 ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate 
• 30122-00-0 α-chloro-benzylisocyanate 
• 21759-71-7 ethyl N-methyl-β-aminocrotonate 
• 930288-11-2 1,6-dimethyl-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid ethyl ester 
• 591-51-5 phenyllithium 
• 3693-54-7 diethyl N,N'-benzylidenebis(carbamate) 
• 74-88-4 methyl iodide 
• 108-86-1 bromobenzene 

Downstream Products

• 123044-15-5 1,6-dimethyl-3-formyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester 
• 113271-92-4 1-methyl-2-oxo-4-phenyl-5-chloro-5-ethoxycarbonyl-6-chloromethylenehexahydropyrimidine 
• 113271-91-3 1-methyl-2-oxo-4-phenyl-5-ethoxycarbonyl-6-dichloromethyl-1,2,3,4-tetrahydropyrimidine 
• 113271-93-5 1-methyl-2-oxo-4-phenyl-5-chloro-5-ethoxycarbonyl-6-dichloromethylenehexahydropyrimidine 
• 82447-98-1 3-Methyl-2-oxo-6-phenyl-2,3-dihydro-pyrimidine-4,5-dicarboxylic acid 5-ethyl ester 
• 95928-50-0 1,6-dimethyl-2-oxo-4-phenyl-1,2-dihydropyrimidine-5-carboxylic acid ethyl ester 
• 189374-16-1 3-(2-Methoxycarbonyl-acetyl)-1,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 
• 82447-97-0 1,6-dimethyl-2-oxo-3-acetyl-4-phenyl-5-ethoxycarbonyl-1,2,3,4-tetrahydropyrimidine 
• 14758-01-1 ethyl 6-(bromomethyl)-1-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro pyrimidine-5-carboxylate 

Relevant academic research and scientific papers

Expedient Synthesis of Biginelli-Type Dihydropyrimidinones Using α-(Benzotriazolyl)alkyl Urea Derivatives

Reaction of readily available α-(benzotriazolyl)alkyl urea derivatives (derived from aromatic, heteroaromatic, and aliphatic aldehydes) with β-keto esters resulted in 3,4-dihydropyrimidin-2(1H)-ones in good to excellent yields.

Highly regioselective addition of organozinc reagents to 2-Oxo-1,2-dihydropyrimidine-5-carboxylates activated by BF3· OEt2: Synthesis of 2-Oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates

The incorporation of alkyl as well as phenyl groups at C-4, a key position of 2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates, responsible for antagonist/agonist switching of the calcium channel blocking activity of these compounds, has been achieved by the addition of organozinc reagents to the corresponding 2-oxo-1,2-dihydropyrimidine-5-carboxylate derivatives catalysed by BF3OEt2. An efficacious diversification of the key C-4 position of 2-oxo-1,2-dihydropyrimidine-5-carboxylates has been achieved through the addition of organozinc reagents.

A highly regio- and chemoselective addition of carbon nucleophiles to pyrimidinones. A new route to C4 elaborated Biginelli compounds

Ethyl 6-methyl-pyrimidine-2-one-5-carboxylates react with C-nucleophiles in a diversity oriented synthetic sequence to afford C4 substituted congeners of medicinally potent Biginelli dihydropyrimidinones, in a highly regioselective manner.

Halogenated macroporous sulfonic resins as efficient catalysts for the Biginelli reaction

A series of halogenated macroporous sulfonic resins A-15-Cl, A-15-Br and A-15-I were synthesized from the precursor Amberlyst 15 by a typical halogenation reaction, and they were evaluated for the catalytic activities of the halogenated macroporous sulfon

Enantioselective N-Acylation of Biginelli Dihydropyrimidines by Oxidative NHC Catalysis

The oxidative N-acylation reaction of 3,4-dihydropyrimidin-2-(1H)-ones (DHPMs) with enals and N-heterocyclic carbene (NHC) catalysts is described. The reaction proceeds in the presence of quinone oxidant without additional acyl transfer agents and in the

Quinolinium Chlorochromate: An Excellent Reagent for N3-C4 Dehydrogenation of Dihydropyrimidinones and their Antifungal Evaluation

To enhance the efficacy of 3,4-dihydropyrimidin-2-ones (DHPMs) as an antifungal agent, their dehydrogenated derivatives, i.e., pyrimidin-2-ones were synthesized employing quinolinium chlorochromate as an oxidizing agent. The synthesized compounds were scr

Synthesis and anticancer activity of new dihydropyrimidinone derivatives

A series of dihydropyrimidinone derivatives bearing various N-heterocyclic moieties was designed and synthesized. Twelve new compounds were screened for their cytotoxic activity using 60 cancer cell lines according to NCI (USA) protocol. Compound 19 showe

(C5H6N4O)(C5H5N4O)3(C5H4N4O)[Bi2Cl11]Cl2 as a simple and efficient catalyst in Biginelli reaction

A highly efficient and facile procedure for the one-pot three-component synthesis of 3,4-dihydropyrimidin-2-(1H)ones/thiones from the one-pot condensation of aldehyde, β-dicarbonyl compound and urea/thiourea was developed. The methodology is applicable to

Synthesizing method for 3,4-dihydropyrimidinone derivative

The invention discloses a synthesizing method for a 3,4-dihydropyrimidinone derivative.The synthesizing method comprises the specific steps that (C5H6N4O)(C5H5N4O)3(C5H4N4O)[Bi2Cl11]Cl2 serves as a catalyst, ethyl alcohol serves as a solvent, a reaction i

Targeting the Hsp90 C-terminal domain by the chemically accessible dihydropyrimidinone scaffold

Hsp90 C-terminal ligands are potential new anti-cancer drugs alternative to the more studied N-terminal inhibitors. Here we report the identification of a new dihydropyrimidinone binding the C-terminus, which is not structurally related to other well-known natural and nature-inspired inhibitors of this second druggable Hsp90 site.