123043-97-0

Basic information

• Product Name: 3,6-dimethyl-2-methylthio-4-phenyl-3,4-dihydropyrimidine-5-carboxylic acid ethyl ester
• Synonyms: 3,6-dimethyl-2-methylthio-4-phenyl-3,4-dihydropyrimidine-5-carboxylic acid ethyl ester
• CAS NO: 123043-97-0
• Molecular Weight: 304.413
• Mol File: 123043-97-0.mol

Chemical Properties

• CAS DataBase Reference: 3,6-dimethyl-2-methylthio-4-phenyl-3,4-dihydropyrimidine-5-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-dimethyl-2-methylthio-4-phenyl-3,4-dihydropyrimidine-5-carboxylic acid ethyl ester(123043-97-0)
• EPA Substance Registry System: 3,6-dimethyl-2-methylthio-4-phenyl-3,4-dihydropyrimidine-5-carboxylic acid ethyl ester(123043-97-0)

Safety Data

• Hazardous Substances Data: 123043-97-0(Hazardous Substances Data)

Upstream product

• 74840-45-2 6-methyl-2-methylthio-4-phenyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester 
• 74-88-4 methyl iodide 
• 74840-45-2 ethyl 6-methyl-2-methylthio-4-phenyl-3,4,5,6-tetrahydropyrimidine-5-carboxylate 
• 123043-88-9 5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione 
• 123044-09-7 2-(2-ethoxycarbonylethyl)thio-6-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester 
• 100-52-7 benzaldehyde 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 123043-98-1 5-ethoxycarbonyl-3,6-dimethyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one 

Relevant articles and documents

Dihydropyrimidine based hydrazine dihydrochloride derivatives as potent urease inhibitors

Four series of heterocyclic compounds 4-dihydropyrimidine-2-thiones 7-12 (series A), N,S-dimethyl-dihydropyrimidines 13-18 (series B), hydrazine derivatives of dihydropyrimidine 19-24 (series C), and tetrazolo dihydropyrimidine derivatives 25-30 (series D

Preparation of dihydrotetrazolo[1,5-a]pyrimidine derivatives from Biginelli 3,4-dihydropyrimidine-2-thiones

Dihydropyrimidines (DHPM) with a fused tetrazole ring have been synthesized via a smooth and efficient three-step protocol involving N,S-dimethylated and 2-hydrazinyl-dihydropyrimidine intermediates, respectively. The described protocol is applicable to e

Synthesis and Reactions of "Biginelli-Compounds". Part I

Various reactions of 2-oxo (or thioxo)-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid derivatives (Biginelli-compounds) were investigated.The site of methylation and acylation on 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester 1a and its 2-oxo derivative 9a was studied.The synthesis of pyrimidothiazines and thiazolopyrimidines was accomplished by condensation of 1a with 1,3- and 1,2-dielectrophiles.A Dimroth-like rearrangement yielding 6H-1,3-thiazines can be observed when 1a was treated with dimethylformamide and phosphorus oxychloride.The formation of indenopyrimidines can be achieved by intramolecular Friedl-Crafts acylation of 9a and 13, respectively.Finally a route for the preparation of 4,6-disubstituted-pyrimidine-5-carbonitriles is presented, starting with Biginelli-compound 25.