123044-09-7

Basic information

• Product Name: 2-(2-ethoxycarbonylethyl)thio-6-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester
• Synonyms: 2-(2-ethoxycarbonylethyl)thio-6-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester
• CAS NO: 123044-09-7
• Molecular Weight: 376.477
• Mol File: 123044-09-7.mol

Chemical Properties

• CAS DataBase Reference: 2-(2-ethoxycarbonylethyl)thio-6-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-ethoxycarbonylethyl)thio-6-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester(123044-09-7)
• EPA Substance Registry System: 2-(2-ethoxycarbonylethyl)thio-6-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester(123044-09-7)

Safety Data

• Hazardous Substances Data: 123044-09-7(Hazardous Substances Data)

Upstream product

• 539-74-2 Ethyl 3-bromopropionate 
• 123043-88-9 5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione 

Downstream Products

• 123044-08-6 8-methyl-4-oxo-6-phenyl-2,3-dihydro-6H-pyrimido<2,3-b>thiazine-7-carboxylic acid ethyl ester 
• 113697-40-8 7-methyl-3-oxo-5-phenyl-2,3-dihydro-5H-thiazolo<3,2-a>pyrimidine-6-carboxylic acid ethyl ester 
• 123044-25-7 7-methyl-5-phenyl-2,3-dihydro-5H-thiazolo<3,2-a>pyrimidine-6-carboxylic acid ethyl ester hydrobromide 
• 123044-26-8 2-amino-4-methyl-6-phenyl-6H-1,3-thiazine-5-carboxylic acid ethyl ester hydrochloride 
• 123043-96-9 6-methyl-2-methylthio-4-phenyl-3-tosyl-3,4-dihydropyrimidine-5-carboxylic acid ethyl ester 
• 123044-06-4 2-isopropyl-7-methyl-3-oxo-5-phenyl-2,3-dihydro-5H-thiazolo<3,2-a>pyrimidine-6-carboxylic acid ethyl ester 
• 123044-05-3 2-ethyl-7-methyl-3-oxo-5-phenyl-2,3-dihydro-5H-thiazolo<3,2-a>pyrimidine-6-carboxylic acid ethyl ester 
• 123044-07-5 2,2,7-trimethyl-3-oxo-5-phenyl-2,3-dihydro-5H-thiazolo<3,2-a>pyrimidine-6-carboxylic acid ethyl ester 
• 123043-94-7 4-methyl-2-methylthio-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylic acid diethyl ester 
• 123043-95-8 3-acetyl-6-methyl-2-methylthio-4-phenyl-3,4-dihydropyrimidine-5-carboxylic acid ethyl ester 
• 123044-12-2 ethyl 2-[(dimethylamino)methyleneamino]-4-methyl-6-phenyl-6H-1,3-thiazine-5-carboxylate 
• 123044-04-2 2,7-dimethyl-3-oxo-5-phenyl-2,3-dihydro-5H-thiazolo<3,2-a>pyrimidine-6-carboxylic acid ethyl ester 
• 111535-64-9 ethyl 3-acetyl-6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 123044-10-0 3-formyl-6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester 

Relevant articles and documents

Synthesis and Reactions of "Biginelli-Compounds". Part I

Various reactions of 2-oxo (or thioxo)-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid derivatives (Biginelli-compounds) were investigated.The site of methylation and acylation on 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester 1a and its 2-oxo derivative 9a was studied.The synthesis of pyrimidothiazines and thiazolopyrimidines was accomplished by condensation of 1a with 1,3- and 1,2-dielectrophiles.A Dimroth-like rearrangement yielding 6H-1,3-thiazines can be observed when 1a was treated with dimethylformamide and phosphorus oxychloride.The formation of indenopyrimidines can be achieved by intramolecular Friedl-Crafts acylation of 9a and 13, respectively.Finally a route for the preparation of 4,6-disubstituted-pyrimidine-5-carbonitriles is presented, starting with Biginelli-compound 25.