111535-64-9Relevant academic research and scientific papers
A Cs2CO3-mediated simple and selective method for the alkylation and acylation of 3,4-dihydropyrimidin-2(1 H)-thiones
Putatunda, Salil,Chakraborty, Arijit
, p. 1057 - 1064 (2014/12/10)
Alkyl and acyl derivatives of 3,4-dihydropyrimidin-2(1H)-thiones were synthesized in good to excellent yields in the presence of Cs2CO3, a mild base. The method evidences a selective S-alkylation when using acyl chlorides as efficien
Synthesis of Acetylated Dihydropyrimidine Analogues under Solvent Free Conditions and their Evaluation as Calcium Channel Blockers
Sati, Bhawana,Sati, Hemlata,Saklani, Sarla,Nargund, L. V. G.,Lamma, E. L.,Khaidem, Somila,Bhatt, Prakash Chandra
, p. 1055 - 1059,5 (2020/08/24)
One pot condensation of ethylacetoacetate with various para and ortho substituted aldehydes and urea or thiourea by SnCI2.2H20 affords eight different substituted 3,4-dihydropyrimidine ones/ thiones. Further we prepared acetylated 3,
Synthesis and Reactions of "Biginelli-Compounds". Part I
Kappe, Christian Oliver,Roschger, Peter
, p. 55 - 64 (2007/10/02)
Various reactions of 2-oxo (or thioxo)-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid derivatives (Biginelli-compounds) were investigated.The site of methylation and acylation on 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester 1a and its 2-oxo derivative 9a was studied.The synthesis of pyrimidothiazines and thiazolopyrimidines was accomplished by condensation of 1a with 1,3- and 1,2-dielectrophiles.A Dimroth-like rearrangement yielding 6H-1,3-thiazines can be observed when 1a was treated with dimethylformamide and phosphorus oxychloride.The formation of indenopyrimidines can be achieved by intramolecular Friedl-Crafts acylation of 9a and 13, respectively.Finally a route for the preparation of 4,6-disubstituted-pyrimidine-5-carbonitriles is presented, starting with Biginelli-compound 25.
