123044-10-0

Usage

InChI:InChI=1/C15H16N2O3S/c1-3-20-14(19)12-10(2)16-15(21)17(9-18)13(12)11-7-5-4-6-8-11/h4-9,13H,3H2,1-2H3,(H,16,21)/t13-/m1/s1

Upstream product

• 123043-88-9 5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione 
• 68-12-2 N,N-dimethyl-formamide 
• 141-97-9 ethyl acetoacetate 
• 100-52-7 benzaldehyde 
• 123044-09-7 2-(2-ethoxycarbonylethyl)thio-6-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester 

Downstream Products

• 123044-14-4 ethyl 1-formyl-4-methyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 123044-12-2 ethyl 2-[(dimethylamino)methyleneamino]-4-methyl-6-phenyl-6H-1,3-thiazine-5-carboxylate 
• 1314021-40-3 ethyl 1,2,3,6-tetrahydro-1-(3-(2-hydroxy-5-methylphenyl)-3-oxoprop-1-enyl)-4-methyl-6-phenyl-2-thioxopyrimidin-5-carboxylate 
• 1314021-51-6 ethyl 1-(3-(5-chloro-2-hydroxyphenyl)-3-oxoprop-1-enyl)-1,2,3,6-tetrahydro-4-methyl-6-phenyl-2-thioxopyrimidin-5-carboxylate 

Relevant academic research and scientific papers

Synthesis and screening of 3-formyl-2-thio-1,2,3,4-tetrahydro pyrimidine analogues as antibacterial agents

5-Acyl-6-methyl-4-substituted-2-thio-1,2,3,4-tetrahydropyrimidines were prepared by cyclocondensation between appropriate aldehyde, acetoacetate and thiourea using aluminium chloride and conc. Hydrochloric acid. These compounds upon treatment with dimethy

Synthesis and reactions of some pyrimidine derivatives

Three different series of compounds including N-formylated thioxopyrimidines 3a-d, thiazine derivatives 4a-c and N-formylated oxopyrimidines 5a-d were synthesized by reaction of an appropriate ethyl 6-methyl-4-aryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-

Synthesis and Reactions of "Biginelli-Compounds". Part I

Various reactions of 2-oxo (or thioxo)-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid derivatives (Biginelli-compounds) were investigated.The site of methylation and acylation on 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester 1a and its 2-oxo derivative 9a was studied.The synthesis of pyrimidothiazines and thiazolopyrimidines was accomplished by condensation of 1a with 1,3- and 1,2-dielectrophiles.A Dimroth-like rearrangement yielding 6H-1,3-thiazines can be observed when 1a was treated with dimethylformamide and phosphorus oxychloride.The formation of indenopyrimidines can be achieved by intramolecular Friedl-Crafts acylation of 9a and 13, respectively.Finally a route for the preparation of 4,6-disubstituted-pyrimidine-5-carbonitriles is presented, starting with Biginelli-compound 25.