123060-92-4

Upstream product

• 123060-91-3 ethyl 3-(m-methylphenylethyl)-2-methyl-4-oxocyclohex-2-encarboxylate 
• 487-51-4 4-carbethoxy-3-methyl-2-cyclohexen-1-one 
• 101668-81-9 C₁₅H₁₆O₃ 
• 1292848-80-6 3-methoxy-2-[2-(3-methylphenyl)ethyl]cyclohex-2-en-1-one 
• 16799-08-9 1-(2-bromoethyl)-3-methylbenzene 

Downstream Products

• 123060-98-0 2-(2-m-methylphenylethyl)-1,3,3-trimethylcyclohexanol 
• 1292848-58-8 7-methyl-6-[2-(3-methylphenyl)ethyl]-1,4-dithiaspiro[4.5]dec-6-ene 
• 1338951-49-7 6-methyl-1-[2-(3-methylphenyl)ethyl]-7-oxabicyclo[4.1.0]heptan-2-one 
• 123060-93-5 2-(m-methylphenylethyl)-3,3-dimethylcyclohexan-1-one 

Relevant academic research and scientific papers

Cationic cyclization of 2-alkenyl-1,3-dithiolanes: Diastereoselective synthesis of trans-decalins

An unprecedented and highly diastereoselective 6-endo-trig cyclization of 2-alkenyl-1,3-dithiolanes has been developed yielding trans-decalins, an important scaffold present in numerous di- and triterpenes. The novelty of this 6-endo-trig cyclization stan

INFLUENCE OF METHOXY- AND METHYL-AROMATIC SUBSTITUENS ON STEREOCHEMISTRY OF THE PRODUCTS IN THE ACID-CATALIZED CYCLIZATION OF 2-(2-ARYLETHYL)-1,3,3-TRIMETHYLCYCLOHEXANOLS: STEREOCONTROLLED TOTAL SYNTHESIS OF (+/-)- NIMBIDIOL AND (+/-)-NIMBIOL

The distributions of the trans- and the cis-podocarpatrienes (5c-g) and (6c-g) in the cyclialkylation reaction of the easily accesible cyclohexanols (4c-g) under a mild condition have been investigated.The cyclohexanol precursors having unactivated aromatic ring proceeds with high stereoselectivity leading to the respective trans-products, while the substrates with an electron donating methoxy or a methyl substituent with respect to the site of electrophilic attack result in the corresponding cis- and the trans-product mixtures.Consistent mechanisms for these stereochemical results have been advanced.Based on these results simple synthesis of the modified diterpenes (+/-)-nimbidiol (7) and (+/-)-nimbiolmethylether (18) have been realized.