245747-08-4

Basic information

• Product Name: Pyr6
• Synonyms: Pyr6;N-{4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-3-fluoroisonicotinamide
• CAS NO: 245747-08-4
• Molecular Formula: C17H9F7N4O
• Molecular Weight: 418.2683824
• Mol File: 245747-08-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 162-163 °C
• Boiling Point: 368.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.52±0.1 g/cm3(Predicted)
• PKA: 9.85±0.70(Predicted)
• CAS DataBase Reference: Pyr6(CAS DataBase Reference)
• NIST Chemistry Reference: Pyr6(245747-08-4)
• EPA Substance Registry System: Pyr6(245747-08-4)

Safety Data

• Hazardous Substances Data: 245747-08-4(Hazardous Substances Data)

Usage

General Description

Pyr6 is a novel compound that does not occur naturally and is commonly used in biological and chemical research. It is a fluorescent dye that can be used to stain cells and tissues, allowing for visualization and analysis under fluorescent microscopy. Pyr6 is also known for its ability to selectively bind to and inhibit Transient Receptor Potential Melastatin 4 (TRPM4) channels, which are involved in the regulation of ion transport across cell membranes. Additionally, Pyr6 has been studied for its potential antifungal and antibacterial properties, making it a versatile and valuable tool in various scientific investigations. Overall, Pyr6 is a versatile compound with applications in biological research, drug discovery, and medical diagnostics.

Upstream product

• 393-53-3 3-fluoroisonicotinic acid 
• 123066-64-8 4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl] aniline 
• 903592-75-6 3-fluoropyridine-4-carbonyl chloride 
• 1522-22-1 1,1,1,5,5,5-hexafluoroacetylacetone 
• 123066-63-7 1-(4-nitrophenyl)-3,5-bis(trifluoromethyl)-1H-pyrazole 
• 636-99-7 4-nitrophenylhydrazine hydrochloride 
• 1694-30-0 1,1,1,5,5,5-hexafluoro-4-hydroxy-pent-3-en-2-one 
• 100-16-3 4-nitrophenylhydrazone 

Relevant articles and documents

Microwave-assisted and continuous flow multistep synthesis of 4-(pyrazol-1-yl)carboxanilides

A series of 4-(pyrazol-1-yl)carboxanilides active as inhibitors of canonical transient receptor potential channels were synthesized in an efficient three-step protocol using controlled microwave heating. The general synthetic strategy involves condensation of 4-nitrophenylhydrazine with appropriate 1,3-dicarbonyl building blocks, followed by reduction of the nitro group to the amine, which is then amidated with carboxylic acids. Compared to the conventional protocol a dramatic reduction in overall processing time from ～2 days to a few minutes was achieved, accompanied by significantly improved product yields. In addition, the first two steps in the synthetic pathway were also performed under continuous flow conditions providing similar isolated product yields. As an alternative to the three-step protocol, a novel two-step route to the desired 4-(pyrazol-1-yl)carboxanilides was devised involving condensation of 4-bromophenylhydrazine with appropriate 1,3-dicarbonyl building blocks, followed by Pd-catalyzed Buchwald-Hartwig amidation with carboxylic acid amides.

3,5-Bis(trifluoromethyl)pyrazoles: A novel class of NFAT transcription factor regulator

A series of bis(trifiuoromethyl)pyrazoles (BTPs) has been found to be a novel inhibitor of cytokine production. Identified initially as inhibitors of IL-2 synthesis, the BTPs have been optimized in this regard and even inhibit IL-2 production with a 10-fold enhancement over cyclosporine in an ex vivo assay. Additionally, the BTPs show inhibition of IL-4, IL-5, IL-8, and eotaxin production. Unlike the IL-2 inhibitors, cyclosporine and FK506, the BTPs do not directly inhibit the dephosphorylation of NFAT by calcineurin.