123168-37-6

Basic information

• Product Name: (2R)-2-ethyl-Pyrrolidine
• Synonyms: (2R)-2-ethyl-Pyrrolidine;2-Ethyl-pyrrolidine.HCl;(R)-2-Ethylpyrrolidine
• CAS NO: 123168-37-6
• Molecular Formula: C₆H₁₃N
• Molecular Weight: 99.17412
• Mol File: 123168-37-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (2R)-2-ethyl-Pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-ethyl-Pyrrolidine(123168-37-6)
• EPA Substance Registry System: (2R)-2-ethyl-Pyrrolidine(123168-37-6)

Safety Data

• Hazardous Substances Data: 123168-37-6(Hazardous Substances Data)

Usage

General Description

"(2R)-2-ethyl-Pyrrolidine" is a type of chemical compound which belongs to the class of organic compounds known as N-Substituted Pyrrolidines. These are compounds containing a Pyrrolidine ring where the nitrogen atom is substituted by a chain with a specific 'R' configuration. In the case of (2R)-2-ethyl-Pyrrolidine, the nitrogen atom is substituted by an ethyl group. Pyrrolidines have applications in pharmaceuticals and synthetic organic chemistry. They are often used as building blocks in the synthesis of more complex molecules. However, specific information about the properties or applications of (2R)-2-ethyl-Pyrrolidine is not readily available and would tend to be determined based on the context of its use.

Upstream product

• 1227910-54-4 phenylmethyl (2R)-2-ethyl-1-pyrrolidinecarboxylate 
• 86661-32-7 (S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate 
• 283610-04-8 (2R)-2-[(2'R)-2'-ethyl-N-pyrrolidinyl]-2-phenyl-1-ethanol 
• 17342-08-4 (S)-Pyroglutaminol 
• 876617-06-0 tert-butyl (2R)-2-ethylpyrrolidine-1-carboxylate 

Relevant articles and documents

CHEMICAL COMPOUNDS

The invention is directed to 6-(4-pyι?midinyl)-1 H-indazole derivatives. Specifically, the invention is directed to compounds according to Formula (I) wherein R1 - R4 are defined herein. The compounds of the invention are inhibitors of PDK1 and can be useful in the treatment of immune and metabolic diseases and disorders characterized by constitutively activated ACG kinases such as cancer and more specifically cancers of the breast, colon, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PDK1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

A simple stereoselective synthesis of enantiopure 2-substituted pyrrolidines and piperidines from chiral (R)-phenylglycinol-derived bicyclic 1,3-oxazolidines

Chiral, nonracemic 2-substituted pyrrolidines and piperidines were prepared in high ee and moderate to good chemical yields in three steps from (R)-phenylglycinol and γ- or δ-chloroketones. The key step of the synthesis was the stereo- selective reductive ring-opening of chiral bicyclic 1,3- oxazolidines prepared by condensation of (R)-phenylglycinol and the corresponding ketones.

Direct Asymmetric Synthesis of Quaternary Carbon Centers via Addition-Elimination Process: Nitroolefination of α-Substituted δ-Lactones

The reactions of chiral nitro enamines 2a-c with zinc enolates 4-6 of α-substituted δ-lactones afforded α,α-disubstituted δ-lactones with a high ee through an addition-elimination process.The best results were obtained with the reaction of 2c with 5.Michael-type addition of the enolate onto the nitro enamine is kinetically controlled and decides the absolute stereochemistry of the product.A cyclic transition model is proposed to rationalize the S-selectivity.