123171-29-9Relevant articles and documents
Design, Synthesis and Biological Evaluation of Highly Potent Simplified Archazolids
Rivière, Solenne,Vielmuth, Christin,Ennenbach, Christiane,Abdelrahman, Aliaa,Lemke, Carina,Gütschow, Michael,Müller, Christa E.,Menche, Dirk
, p. 1348 - 1363 (2020/06/17)
The archazolids are potent antiproliferative compounds that have recently emerged as a novel class of promising anticancer agents. Their complex macrolide structures and scarce natural supply make the development of more readily available analogues highly important. Herein, we report the design, synthesis and biological evaluation of four simplified and partially saturated archazolid derivatives. We also reveal important structure-activity relationship data as well as insights into the pharmacophore of these complex polyketides.
Supported Gold Nanoparticle-Catalyzed Hydration of Alkynes under Basic Conditions
Liang, Shengzong,Jasinski, Jacek,Hammond, Gerald B.,Xu, Bo
supporting information, p. 162 - 165 (2015/07/28)
TiO2-supported nanosize gold particles catalyze the hydration of alkynes using morpholine as a basic cocatalyst. Unlike most homogeneous cationic gold catalysts, the TiO2-Au/morpholine system is weakly basic and is compatible with acid-sensitive functional groups (e.g., silyl ethers, ketals) or with a strongly coordinating group such as pyridine. What's more, this gold catalyst can be recycled by simple filtration and works well in flow reactors. (Chemical Equation Presented).
Formation of α-hydroxyketones via irregular Wittig reaction
Okada, Hideki,Mori, Tomonori,Saikawa, Yoko,Nakata, Masaya
supporting information; experimental part, p. 1276 - 1278 (2009/09/05)
Αddition reactions of (1-methoxyalkyl)triphenylphosphonium ylides, derived from the corresponding Wittig salts and n-BuLi, to aldehydes were investigated. It was revealed that the betaine LiX complexes, the primary adducts, were converted to α-hydroxyketones, prior to the formation of oxaphosphetanes, by addition of aqueous NH4Cl at low temperature.
