1231930-42-9

Basic information

• Product Name: 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-
• Synonyms: 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-;6-(2-chloro-5-fluoropyriMidin-4-yl)-4-fluoro-1-isopropyl-2-Methyl-1H-benzo[d]iMidazole;6-(2-chloro-5-fluoro-pyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzoimidazole;6-(2-chloro-5-fluoropyriMidin-4-yl)-4-fluoro;6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-1H-BenziMidazole;LY2835219 intermediate;6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-2-methyl-1-(propan-2-yl)-1H-1,3-benzodiazole;Abemaciclib intermediate
• CAS NO: 1231930-42-9
• Molecular Formula: C₁₅H₁₃ClF₂N₄
• Molecular Weight: 322.7403264
• Mol File: 1231930-42-9.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 509.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.42±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.32±0.10(Predicted)
• CAS DataBase Reference: 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-(1231930-42-9)
• EPA Substance Registry System: 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-(1231930-42-9)

Safety Data

• Hazardous Substances Data: 1231930-42-9(Hazardous Substances Data)

Usage

Flammability and Explosibility

Notclassified

Upstream product

• 2927-71-1 2,4-dichloro-5-fluoropyrimidine 
• 1231930-33-8 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 
• 42717-36-2 N-isopropylethanimidamide 
• 67567-26-4 4-bromo-2,6-difluoroaniline 
• 1231930-29-2 N-(4-bromo-2,6-difluorophenyl)-N'-isopropylacetamidine 
• 1118-69-0 N-isopropylacetamide 
• 1231930-37-2 4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-benzo[d]imidazole 

Downstream Products

• 1231930-82-7 LY2835219 

Relevant articles and documents

A 2-aminopyrimidine heterocyclic compound and its applications

The present invention discloses a 2-aminopyrimidine heterocyclic compound having a general formula I structure and its applications, which are kinase CDK4, CDK6 and / or CDK9 inhibitors, can be more widely used in the treatment of a variety of cancers, ha

A pyrimidine compound and its application

The present invention discloses a pyrimidine amine compound having a general formula I structure and its applications, the class of compounds belongs to the kinase CDK4, CDK6 and / or CDK9 inhibitors, can be more widely used in the treatment of a variety

DEGRADATION OF CYCLIN-DEPENDENT KINASE 4/6 (CDK4/6) BY CONJUGATION OF CDK4/6 INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE

The present application provides bifunctional compounds, or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which act as protein degradation inducing moieties for cyclin-dependent kinase 4 (CDK4) and/or cyclin-dependent kinase 6 (CDK6). The present application also relates to methods for the targeted degradation of CDK4 and/or CDK6 through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to CDK4 and/or