1232035-08-3

Upstream product

• 1232038-73-1 8-bromo-2-(tetrahydropyran-4-yl)imidazo[1,2-a]pyridine 
• 13534-99-1 2-Amino-3-bromopyridine 
• 141095-78-5 2-bromo-1-(tetrahydro-2H-pyran-4-yl)-ethan-1-one 
• 958245-17-5 1-(2-methoxy-4-nitrophenyl)-4-methyl-1H-imidazole 
• 1009-36-5 2-chloro-5-nitroanisole 
• 958245-18-6 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline 
• 137052-08-5 1-(tetrahydro-2H-pyran-4-yl)ethan-1-one 

Relevant academic research and scientific papers

Design and Synthesis of a Novel Series of Bicyclic Heterocycles As Potent γ-Secretase Modulators

The design and the synthesis of several chemical subclasses of imidazole containing γ-secretase modulators (GSMs) is described. Conformational restriction of pyridone 4 into bicyclic pyridone isosteres has led to compounds with high in vitro and in vivo p

SUBSTITUTED BICYCLIC IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS

The present invention is concerned with novel substituted bicyclic imidazole derivatives of Formula (I) wherein R0, R1, R3, R4, X, A1, A2, A3, A4, Y1, Y2 and Y3 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said novel compound as an active ingredient as well as the use of said compounds as a medicament.