1232634-50-2Relevant articles and documents
Synthesis and molecular design of mono aspirinate thiourea-azo hybrid molecules as potential antibacterial agents
Ngaini, Zainab,Rasin, Ferlicia,Wan Zullkiplee, Wan Sharifatun H.,Abd Halim, Ainaa Nadiah
, p. 275 - 282 (2020)
New mono aspirinate thiourea-azo derivatives 2a–f were synthesized using aspirin as a natural product-based precursor, with 4-aminophenylazophenol derivatives in excellent 70–90% yields. Overall, 2a–f gave excellent antibacterial activity against Staphylo
In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines
Abd Halim, Ainaa Nadiah,Hwang, Siaw San,Lawai, Vannessa,Lee, Boon Kiat,Linton, Reagan Entigu,Neilsen, Paul Matthew,Ngaini, Zainab,Nordin, Norsyafikah Asyilla
, p. 1505 - 1514 (2020)
In searching for drugs from natural product scaffolds has gained interest among researchers. In this study, a series of twelve halogenated thiourea (ATX 1-12)via chemical modification of aspirin (a natural product derivative) and evaluated for cytotoxic a
Novel Synthetic Monothiourea Aspirin Derivatives Bearing Alkylated Amines as Potential Antimicrobial Agents
Nordin, Norsyafikah Asyilla,Chai, Tchan Wei,Tan, Bee Ling,Choi, Ching Liang,Abd Halim, Ainaa Nadiah,Hussain, Hasnain,Ngaini, Zainab
, (2017/02/19)
A new series of aspirin bearing alkylated amines moieties 1-12 were synthesised by reacting isothiocyanate with a series of aniline derivatives in overall yield of 16-56%. The proposed structures of all the synthesised compounds were confirmed using elemental analysis, FTIR, and 1H and 13C NMR spectroscopy. All compounds were evaluated for antibacterial activities against E. coli and S. aureus via turbidimetric kinetic and Kirby Bauer disc diffusion method. Compound 5 bearing meta -CH3 substituent showed the highest relative inhibition zone diameter against tested bacteria compared to ortho and para substituent. Furthermore, aspirin derivatives bearing shorter chains exhibited better bacterial inhibition than longer alkyl chains.
Synthesis and in vitro anticancer activity of novel 2-((3-thioureido) carbonyl)phenyl acetate derivatives
Xiong, Lin,Gao, Ya-Qin,Niu, Chu-E.,Wang, Hong-Bo,Li, Wei-Hong
, p. 132 - 137 (2014/03/21)
Novel simplified Aspirin derivatives were developed, characterized by using IR, 1H NMR, 13C NMR and elementalanalysis techniques and evaluated for anticancer activity in human cell lines. The results revealed that most of the compounds exhibited inhibitory effects of growth of cancer cell lines in vitro against T-acute lymphoblastic leukemia cell lines Molt-4, chronic myclogenous leukemia cell lines K-562, acute myelocytic leukemia cells lines HL-60, human breast cancer cell lines MCF-7, human hepatic carcinoma cell lines HepG-2 and human lung cancer cell lines A-549. It was observed that some of these compounds exhibited significant anticancer activity particularly 5i which had stronger antileukemia activity with IC50 values ranging from 11.12 to 19.25 μmol·L-1 against 3 leukemia cells than control fluorouracil, so some of the compounds may constitute a novel class of anticancer medicines, which deserves further study.
Efficient synthesis of new (R)-2-amino-1-butanol derived ureas, thioureas and acylthioureas and in vitro evaluation of their antimycobacterial activity
Dobrikov, Georgi M.,Valcheva, Violeta,Nikolova, Yana,Ugrinova, Iva,Pasheva, Evdokia,Dimitrov, Vladimir
supporting information, p. 468 - 473 (2013/07/25)
The synthesis of 22 structurally diverse urea, thiourea and acylthiourea derivatives containing the (R)-2-amino-1-butanol motif has been performed. The evaluation of their in vitro activity against Mycobacterium tuberculosis (H 37Rv and strain
Synthesis and antibacterial activity of acetoxybenzoyl thioureas with aryl and amino acid side Chains
Ngaini, Zainab,Mohd Arif, Maya Asyikin,Hussain, Hasnain,Mei, Er Su,Tang, Donna,Kamaluddin, Dyg Halimatulzahrah Abang
experimental part, p. 1 - 7 (2012/03/27)
A series of acetoxybenzoylthioureas derivatives with aryl and amino acid ester side chains were prepared by reaction of acetoxybenzoyl isothiocyanate, an acyloxy benzyl ester-based derivative of aspirin, with aryl amines or amino-functionalized amino acids with overall yields of 46-73%. The products that display a thiourea segment as a linker showed improved antibacterial properties in comparison with aspirin. The structures of the synthesized compounds were characterized by infra red spectroscopy, 13C nuclear magnetic resonance (NMR), and 1H NMR spectroscopy. The compounds were screened for their antibacterial activity by using gram-negative bacteria (E. coli ATCC 8739). [2-(phenylcarbamothioylcarbamoyl)phenyl] acetate showed the highest antibacterial activity against E. coli compared with other synthesized compounds. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. Copyright Taylor and Francis Group, LLC.
