1232829-58-1Relevant academic research and scientific papers
Cobalt-catalyzed carbon-carbon bond formation: Synthesis and applications of enantiopure pyrrolidine derivatives[1]
Hsu, Shih-Fan,Ko, Chih-Wei,Wu, Yao-Ting
, p. 1756 - 1762 (2011/09/20)
In the presence of cobalt catalysts and tetramethylethylenediamine (TMEDA), the iodine atom in (S)-2-(iodomethyl)pyrrolidines was replaced by an aryl or an alkynyl group from the corresponding Grignard reagent, and the coupling products were obtained in good to excellent yields (16 examples; 75-94% yields). The scope and limitations of this protocol were examined. The stereochemistry of the pyrrolidines was unaffected by the reaction conditions. The coupling products are important building blocks of phenanthroindolizidine alkaloids. Palladium-catalyzed formal [4+2] cycloaddition of 2,2′-diiodobiphenyl with the thus-generated (S)-2-(3-trimethylsilyl-2-propynyl)pyrrolidine gave a good yield of the desilylated phenanthrene, which was then converted into unnatural (+)-(S)-tylophorine by the Pictet-Spengler cyclization. Copyright
CYCLIC AMINE COMPOUNDS
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Page/Page column 49, (2011/10/19)
Problems to be solved are to provide novel low-molecular compounds which exhibit calcium receptor antagonist activity, and which are highly safe and orally administrable. As a means for solving the problems, compounds having the Formula (I) or pharmaceuti
Asymmetric palladium-catalyzed carboamination reactions for the synthesis of enantiomerically enriched 2-(Arylmethyl)- and 2-(Alkenylmethyl)pyrrolidines
Mai, Duy N.,Wolfe, John P.
supporting information; experimental part, p. 12157 - 12159 (2010/11/03)
The enantioselective synthesis of 2-(arylmethyl)- and 2-(alkenylmethyl) pyrrolidine derivatives via Pd-catalyzed alkene carboamination reactions is described. These transformations generate enantiomerically enriched products with up to 94% ee from readily
