123294-75-7

Upstream product

• 123294-74-6 (E)-4-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-2-methyl-but-2-enoic acid 

Downstream Products

• 123294-76-8 (R)-1-[(E)-4-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-2-methyl-but-2-enoyl]-pyrrolidine-2-carboxylic acid 
• 123294-77-9 (3R,8aR)-3-[1-Bromo-2-(2,5-dimethoxy-3,4,6-trimethyl-phenyl)-ethyl]-3-methyl-tetrahydro-pyrrolo[2,1-c][1,4]oxazine-1,4-dione 
• 123294-78-0 (3S,8aR)-3-[2-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-ethyl]-3-methyl-tetrahydro-pyrrolo[2,1-c][1,4]oxazine-1,4-dione 
• 53101-49-8 (S)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 

Relevant academic research and scientific papers

Novel Synthesis of (S)-(-)-Chroman-2-carboxylic Acid, Vitamin E Precursor

A new strategy to the synthesis of (S)-(-)-chroman-2-carboxylic acid, a pivotal intermediate possessing the absolute configuration required for the construction of α-tocopherol, was disclosed by utilizing asymmetric halolactonization of acylproline.Debromination followed by acidic hydrolysis directly afforded the title compound in 98percent enantiomer excess.