Novel Synthesis of (S)-(-)-Chroman-2-carboxylic Acid, Vitamin E Precursor

DOI: 10.1246/cl.1989.465

Source and publish data:

Chemistry Letters p. 465 - 466 (1989)

Update date:2022-07-30

Topics:

Authors:

Yoda, Hidemi

Takabe, Kunihiko

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1246/cl.1989.465

A new strategy to the synthesis of (S)-(-)-chroman-2-carboxylic acid, a pivotal intermediate possessing the absolute configuration required for the construction of α-tocopherol, was disclosed by utilizing asymmetric halolactonization of acylproline.Debromination followed by acidic hydrolysis directly afforded the title compound in 98percent enantiomer excess.

Full text of DOI:10.1246/cl.1989.465

Products guided by the article

Product name:(E)-4-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-2-methyl-but-2-enoyl chloride

Cas No:123294-75-7

R&D Labs maybe for 123294-75-7

Tianjin Crest Pharmaceutical R&D Co., Ltd. （Tianjin Yao Technology Development Co., Ltd.）(expird)

Contact:+86-22-66211386

Address:Building B5-405, No, 80 4th Avenue, TEDA, Tianjin, China P.R. 300457
Zibo Ocean International Trade Co.,Ltd(expird)

Contact:+86 533 5160706

Address:1117, Hongtai Bld., Songling rd, Zichuan,Zibo,Shandong,China
Guangxi Nanning Guangtai Agriculture Chemical Co.,Ltd

Contact:+86-771-2311266

Address:Room703,Building12, Software Park Phase II,NO.68,Keyuan Road,Nanning City,Guangxi,China
SHANGHAI RC CHEMICALS CO.,LTD.

website:http://www.rcc.net.cn

Contact:+86-21-50322175

Address:Rm1415 Yinqiao Masion No.58 Jinxin Road Pudong Shanghai China
Shanghai Bojing Chemical Co., Ltd.

Contact:021-37122233

Address:6F Buildiing 11,No.388,Baifu Road,District Fengxian.Shanghai, China.

Relevant to this article

Formal 2 + 2 and 3 + 2 cycloaddition reactions of 2H-chromenes with 2-alkoxy-1,4-benzoquinones: Regioselective synthesis of substituted pterocarpans

Doi:10.1021/jo00291a027
(1990)
Concerning the mechanism of the Peterson olefination reaction

Doi:10.1021/jo00284a041
(1989)
Design and synthesis of 10-alkoxy-5, 6-dihydro-triazolo[4,3-d]benzo[f][1,4] oxazepine derivatives with anticonvulsant activity

Doi:10.1016/j.ejmech.2010.03.041
(2010)
Cellular uptake of a polypyridyl ruthenium complex revealed using a fluorescent rhodamine-modified ruthenium complex

Doi:10.1002/jccs.201200172
(2012)
Catalytic S_N2′-selective substitution of allylic chlorides with arylboronic esters

Doi:10.1021/ol101171v
(2010)
A rare case of solution and solid state inter-conversion of two copper(II) dimers and a copper(II) chain

Doi:10.1016/j.ica.2011.07.027
(2011)

Article Doi