Novel Synthesis of (S)-(-)-Chroman-2-carboxylic Acid, Vitamin E Precursor

DOI: 10.1246/cl.1989.465

Source and publish data:

Chemistry Letters p. 465 - 466 (1989)

Update date:2022-07-30

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Authors:

Yoda, Hidemi

Takabe, Kunihiko

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Article abstract of DOI:10.1246/cl.1989.465

A new strategy to the synthesis of (S)-(-)-chroman-2-carboxylic acid, a pivotal intermediate possessing the absolute configuration required for the construction of α-tocopherol, was disclosed by utilizing asymmetric halolactonization of acylproline.Debromination followed by acidic hydrolysis directly afforded the title compound in 98percent enantiomer excess.

Full text of DOI:10.1246/cl.1989.465

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