1233142-91-0Relevant academic research and scientific papers
4-AZAINDOLE COMPOUNDS
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, (2019/07/03)
Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9
Diverse ring opening of thietanes and other cyclic sulfides: An electrophilic aryne activation approach
Zheng, Tianyu,Tan, Jiajing,Fan, Rong,Su, Shuaisong,Liu, Binbin,Tan, Chen,Xu, Kun
, p. 1303 - 1306 (2018/02/14)
Organosulfides are a common class of structure units in bioactive molecules and functional materials motivating continuous developments of efficient synthetic methods. Herein, we report an electrophilic aryne-activated ring opening protocol of one or two
Polycyclic Sulfoximines as New Scaffolds for Drug Discovery
Borst, Mark L. G.,Ouairy, Cécile M. J.,Fokkema, Sander C.,Cecchi, Alessandro,Kerckhoffs, Jessica M. C. A.,De Boer, Vincent L.,Van Den Boogaard, Peter J.,Bus, Rutger F.,Ebens, Rijko,Van Der Hulst, Rob,Knol, Joop,Libbers, Rob,Lion, Zhou M.,Settels, Bart W.,De Wever, Ellen,Attia, Khaled A.,Sinnema, Piet-Jan,De Gooijer, Jesse M.,Harkema, Karen,Hazewinkel, Marieke,Snijder, Susan,Pouwer, Kees
, p. 335 - 343 (2018/05/14)
The design and synthesis of three novel polycyclic scaffolds containing sulfoximines are presented in this work, which exemplify that sulfoximines represent a real opportunity for the discovery of new drug candidates. Additionally, the structures present at least two points of diversification and contain a high level of sp3-character, hence being very interesting 3D scaffolds. The compounds synthesized were added to the compound collection of the European Lead Factory.
SUBSTITUTED PHENYLOXAZOLIDINONES FOR ANTIMICROBIAL THERAPY
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, (2017/02/09)
The present invention relates to novel oxazolidinones (Formula I): or a pharmaceutically acceptable salt having ring A characterized by N-containing monocyclic, bicyclic or spirocyclic substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.
Synthesis of azaspirocycles and their evaluation in drug discovery
Burkhard, Johannes A.,Wagner, Bjoern,Fischer, Holger,Schuler, Franz,Mueller, Klaus,Carreira, Erick M.
supporting information; experimental part, p. 3524 - 3527 (2010/08/06)
(Figure Presented). Make It spirol Readily synthesized heteroatom- substituted spiro[3.3]heptanes generally show higher aqueous solubility than their cyclohexane analogues, and show a trend towards higher metabolic stability. The novel framework can be mo
