13573-28-9

Basic information

• Product Name: 6-(p-toluenesulfonyl)-2-o...
• Synonyms: 6-(p-toluenesulfonyl)-2-o...;6-[(4-Methylphenyl)sulfonyl]-2-oxa-6-azaspiro[3.3]heptane;6-(p-toluenesulfonyl)-2-oxa-6-azaspiro[3.3]heptane;2-Oxa-6-azaspiro[3.3]heptane, 6-[(4-Methylphenyl)sulfonyl]-;6-(4-methylbenzenesulfonyl)-2-oxa-6-azaspiro[3.3]heptane
• CAS NO: 13573-28-9
• Molecular Formula: C₁₂H₁₅NO₃S
• Molecular Weight: 253.3174
• Mol File: 13573-28-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 411°C at 760 mmHg
• Flash Point: 202.3°C
• Appearance: /
• Density: 1.37g/cm³
• Vapor Pressure: 5.79E-07mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: 2-8°C
• PKA: -6.15±0.20(Predicted)
• CAS DataBase Reference: 6-(p-toluenesulfonyl)-2-o...(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(p-toluenesulfonyl)-2-o...(13573-28-9)
• EPA Substance Registry System: 6-(p-toluenesulfonyl)-2-o...(13573-28-9)

Safety Data

• Hazardous Substances Data: 13573-28-9(Hazardous Substances Data)

Usage

General Description

6-(p-toluenesulfonyl)-2-o-nitrobenzamide is a chemical compound with the molecular formula C14H12N2O5S, containing an amide group attached to a benzene ring that has been substituted with a para-toluenesulfonyl group and a nitro group. It is often used in organic synthesis as a reagent or building block due to its ability to undergo various reactions. 6-(p-toluenesulfonyl)-2-o... is known to participate in nucleophilic substitution reactions, where the tosyl group serves as a good leaving group. Additionally, the nitro group in the benzene ring can undergo reduction reactions to form amine derivatives, making it useful in the synthesis of various pharmaceutical compounds. Its unique combination of functional groups allows for a wide range of chemical transformations, making it a valuable component in organic chemistry research.

InChI:InChI=1/C12H15NO3S/c1-10-2-4-11(5-3-10)17(14,15)13-6-12(7-13)8-16-9-12/h2-5H,6-9H2,1H3

Upstream product

• 1522-92-5 2,2-bis(bromomethyl)-3-bromo-propan-1-ol 
• 70-55-3 toluene-4-sulfonamide 

Downstream Products

• 174-78-7 2-oxa-6-azaspiro[3.3]heptane 
• 1041026-55-4 (3-(bromomethyl)-1-(p-toluenesulfonyl)azetidin-3-yl)methanol 
• 1041026-61-2 3,3-bis(bromomethyl)-1-(p-toluenesulfonyl)azetidine 

Relevant articles and documents

Nickel-Catalyzed Esterification of Amides Under Mild Conditions

Abstract: The use of ligands to adjust the catalytic activity of the catalyst for esterification of amides is challenge in organic chemistry. In this paper, Nickel(II)-NHC-catalyzed the esterification reaction between N,N-di-Boc amide and alcohols at room temperature have been demonstrated. The imidazolium salt bearing a hydroxyl functionalized side arm showed high effective catalytic activity in the activation of the amide N–C bond in air atmosphere. Graphic Abstract: [Figure not available: see fulltext.].

Polycyclic Sulfoximines as New Scaffolds for Drug Discovery

The design and synthesis of three novel polycyclic scaffolds containing sulfoximines are presented in this work, which exemplify that sulfoximines represent a real opportunity for the discovery of new drug candidates. Additionally, the structures present at least two points of diversification and contain a high level of sp3-character, hence being very interesting 3D scaffolds. The compounds synthesized were added to the compound collection of the European Lead Factory.

SUBSTITUTED PHENYLOXAZOLIDINONES FOR ANTIMICROBIAL THERAPY

The present invention relates to novel oxazolidinones (Formula I): or a pharmaceutically acceptable salt having ring A characterized by N-containing monocyclic, bicyclic or spirocyclic substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.