1233249-63-2

Basic information

• Product Name: methyl [1-({4-[2-(4-chlorophenyl)ethoxy]phenyl}carbonyl)isoquinolin-4-yl]acetate
• Synonyms: methyl [1-({4-[2-(4-chlorophenyl)ethoxy]phenyl}carbonyl)isoquinolin-4-yl]acetate
• CAS NO: 1233249-63-2
• Molecular Weight: 459.929
• Mol File: 1233249-63-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl [1-({4-[2-(4-chlorophenyl)ethoxy]phenyl}carbonyl)isoquinolin-4-yl]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl [1-({4-[2-(4-chlorophenyl)ethoxy]phenyl}carbonyl)isoquinolin-4-yl]acetate(1233249-63-2)
• EPA Substance Registry System: methyl [1-({4-[2-(4-chlorophenyl)ethoxy]phenyl}carbonyl)isoquinolin-4-yl]acetate(1233249-63-2)

Safety Data

• Hazardous Substances Data: 1233249-63-2(Hazardous Substances Data)

Upstream product

• 1233249-53-0 1-[(4-methoxyphenyl)carbonyl]isoquinoline-4-carboxylic acid 
• 1233249-54-1 methyl {1-[(4-methoxyphenyl)carbonyl]isoquinolin-4-yl} acetate 
• 1875-88-3 2-(4-Chlorophenyl)ethanol 
• 1233249-55-2 methyl {1-[(4-hydroxyphenyl)carbonyl]isoquinolin-4-yl} acetate 
• 1233249-52-9 methyl 1-[(4-methoxyphenyl)carbonyl]isoquinoline-4-carboxylate 
• 104-47-2 p-methoxybenzylnitrile 
• 37497-86-2 1-chloro-isoquinoline-4-carboxylic acid methyl ester 
• 1233249-60-9 4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-l-yl]carbonyl}benzoic acid 
• 1233249-59-6 tert-butyl 4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]carbonyl}benzoate 

Downstream Products

• 1233248-17-3 2-[1-[4-[2-(4-chlorophenyl)ethoxy]benzoyl]isoquinolin-4-yl]acetic acid 

Relevant articles and documents

Isoquinoline derivatives as potent CRTH2 antagonists: Design, synthesis and SAR

In this study, we describe the synthesis and structure-activity relationship (SAR) of a series of isoquinoline chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonists. TASP0376377 (15-20), one of the most potent compounds, showed a potent binding affinity (IC50 = 19 nM) in addition to the excellent functional antagonist activity (IC50 = 13 nM). Moreover, the efficacy of this compound in a chemotaxis assay (IC50 = 23 nM) was in good agreement with its potency as a CRTH2 antagonist. In addition, 15-20 exhibited greater selectivity in binding to CRTH2 than to the DP1 prostanoid receptor (IC 50 >1 μM) or the enzymes COX-1 and COX-2 (IC50 >10 μM).