1233249-89-2

Upstream product

• 998-40-3 tributylphosphine 
• 108052-76-2 4-(bromomethyl)benzoic acid 1,1-dimethylethyl ester 

Downstream Products

• 1233249-90-5 methyl 1-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]isoquinoline-4-carboxylate 
• 1233248-29-7 2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetic acid 
• 1233249-91-6 1-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]isoquinoline-4-carboxylic acid 
• 1233249-93-8 4-[[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]methyl]benzoic acid 
• 1233249-94-9 methyl 2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetate 
• 1233249-95-0 methyl (1-{4-[(2-phenyl ethyl)carbamoyl]benzyl}isoquinolin-4-yl)acetate 
• 1233250-06-0 tert-butyl 4-[[4-(1-methoxy-1-oxopropan-2-yl)isoquinolin-1-yl]methyl]benzoate 
• 1233249-29-0 4-[[4-(2-amino-2-oxoethyl)isoquinolin-1-yl]methyl]-N-[2-(4-chlorophenyl)ethyl]benzamide 
• 1233249-30-3 N-[2-(4-chlorophenyl)ethyl]-4-[[4-(1H-tetrazol-5-ylmethyl)isoquinolin-1-yl]methyl]benzamide 
• 1233250-12-8 N-[2-(4-chlorophenyl)ethyl]-4-[[4-(cyanomethyl)isoquinolin-1-yl]methyl]benzamide 
• 1233249-31-4 N-[2-(4-chlorophenyl)ethyl]-4-({4-[2-(hydroxyamino)-2-oxoethyl]isoquinolin-1-yl}methyl)benzamide 
• 1233250-13-9 N-[2-(4-chlorophenyl)ethyl]-4-[(4-{2-oxo-2-[(tetrahydro-2H-pyran-2-yloxy)amino]ethyl}isoquinolin-1-yl)methyl]benzamide 
• 1233248-93-5 2-[1-[[4-(methylcarbamoyl)phenyl]methyl]isoquinolin-4-yl]acetic acid 
• 1233248-34-4 C₂₅H₁₈Cl₂N₂O₃ 

Relevant academic research and scientific papers

Isoquinoline derivatives as potent, selective, and orally active CRTH2 antagonists

Synthesis and structure-activity relationship of a novel series of isoquinoline CRTH2 antagonists bearing a methylene linker between the isoquinoline and benzamide moieties were described. Optimization focusing on the substituents of the benzamide portion in the right hand part of the molecule led to the identification of TASP0412098 (9l), which is a potent, selective CRTH2 antagonist (binding affinity: IC50=2.1 nM, functional activity: IC50=12 nM). Compound 9l, which was orally bioavailable in mice and guinea pigs, showed in vivo efficacy after oral administration in a bronchial asthma model of guinea pigs.

ISOQUINOLINE DERIVATIVE

A compound represented by formula (I) or a pharmaceutically acceptable salt thereof has an effect of inhibiting CRTH2 and, therefore, is useful as a pharmaceutical.

ISOQUINOLINE DERIVATIVE

A compound represented by formula (I) or a pharmaceutically acceptable salt thereof has an effect of inhibiting CRTH2 and, therefore, is useful as a preventive or a remedy for allergic diseases such as asthma, atopic dermatitis and allergic rhinitis.