1233851-13-2Relevant articles and documents
Catalytic asymmetric 1,3-dipolar cycloaddition of α-iminonitriles
Robles-Machín, Rocío,Alonso, Inés,Adrio, Javier,Carretero, Juan C.
, p. 5286 - 5291 (2010)
(Figure Presented) Improving the structural scope: A catalytic asymmetric 1,3-dipolar cycloaddition involving α-iminonitriles as azomethine precursors has been developed. In the presence of AgOAc/ Taniaphos as the catalyst system the reaction of α-iminonitriles with dimethyl fumarate and N-methyl maleimide affords 2-cyanopyrrolidines with good endo selectivity and enantioselectivity (68-≥99% ee; see scheme).