123419-93-2

Upstream product

• 100981-05-3 5-[bis(methylthio)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 62-53-3 aniline 
• 74-89-5 methylamine 
• 2033-24-1 cycl-isopropylidene malonate 
• 103-72-0 phenyl isothiocyanate 
• 74-88-4 methyl iodide 
• 125674-06-8 2,2-dimethyl-5-[(phenylamino)(sulfanyl)methylidene]-1,3-dioxane-4,6-dione 

Downstream Products

• 174742-20-2 2,2-dimethyl-5--1,3-dioxane-4,6-dione 
• 123420-04-2 2-methylthioquinolin-4(1H)-one 
• 145355-48-2 phenyliminopropadienone 
• 123419-94-3 5-<4-Bromophenylamino(methylthio)methylene>-2,2-dimethyl-4,6-dioxo-1,3-dioxane 
• 442520-33-4 5-{[2-(3,4-dimethoxy-phenyl)-ethylamino]-phenylamino-methylene}-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 442520-30-1 5-(butylamino-phenylamino-methylene)-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 126990-02-1 5-(Bis-phenylamino-methylene)-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 351001-90-6 5-[2-Benzylanilino(morpholino)methylene]-2,2-dimethyl-4,6-dioxo-1,3-dioxane 
• 62-53-3 aniline 
• 442520-40-3 5-{(4-bromo-phenylamino)-[2-(3,4-dimethoxy-phenyl)-ethylamino]-methylene}-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 442520-37-8 5-[(4-bromo-phenylamino)-(4-methyl-piperazin-1-yl)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione 

Relevant academic research and scientific papers

Mechanistic studies of a "declick" reaction

A kinetic analysis of a "declick" reaction is described. Compound 1, previously reported to couple an amine and a thiol (i.e. "click") under mild aqueous conditions to create 2, undergoes release of the unaltered coupling partners upon triggering with dit

Convenient synthesis of 5-(arylamino(alkylthio)methylene)-2,2-dimethyl-1,3-dioxane-4,6-diones and 2-arylthio-4-quinolones

Meldrum's acid reacted with an aryl isothiocynate and alkyl halides to afford the 5-(arylamino(alkylthio)methylene)-5-methylthio-2,2-dimethyl-1,3-dioxane-4, 6-diones and the compounds underwent thermal cyclization to give the 4-2-arylthio-4(1H)-quinolones.

Synthesis of 2-amino-1,4-dihydro-4-quinolinones and diaminomethylene Meldrum's acids derivatives as potential potassium channel openers

Starting from 5-bismethylthiomethylene Meldrum's acid, the synthesis of 5-diaminomethylene Meldrum's acids and 2-aminoquinolone derivatives, structurally related to potassium channels openers pinacidil and diazoxide, is described.

Iminopropadienones, RN=C=C=C=O: Syntheses and Reactions

Phenyliminopropadienone, PhN=C=C=C=O, is prepared and characterized, and initial chemical reactions are described.

Reactions of Meldrum's Acid with Isocyanates and Isothiocyanates

Meldrum's acid (1) reacts with isothiocyanates and LiH as base, yielding after alkylation the ketene-S,N-acetales 3, 4 and 5.Protonation of the lithium-thiolate 2 gives the thioamides 7 with tautomers 8, which can be methylated with diazomethane to 9.From