123455-91-4

Basic information

• Product Name: Benzene, (4,4-difluoro-1-methyl-3-butenyl)-
• CAS NO: 123455-91-4
• Molecular Formula: C11H12F2
• Molecular Weight: 182.213
• Mol File: 123455-91-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzene, (4,4-difluoro-1-methyl-3-butenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, (4,4-difluoro-1-methyl-3-butenyl)-(123455-91-4)
• EPA Substance Registry System: Benzene, (4,4-difluoro-1-methyl-3-butenyl)-(123455-91-4)

Safety Data

• Hazardous Substances Data: 123455-91-4(Hazardous Substances Data)

Upstream product

• 433-06-7 2,2,2-Trifluoroethyl p-toluenesulfonate 
• 98-83-9 isopropenylbenzene 
• 2236129-81-8 trifluoroacetaldehyde N-triftosylhydrazone 
• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 16251-77-7 3-Phenylbutyraldehyde 
• 51136-87-9 tris(2-phenylpropyl)borane 

Downstream Products

• 19832-98-5 4-methyl-3,4-dihydro-2H-naphthalen-1-one 

Relevant articles and documents

Coupling of Trifluoroacetaldehyde N-Triftosylhydrazone with Organoboronic Acids for the Synthesis of gem-Difluoroalkenes

The synthesis of alkyl gem-difluoroalkenes remains a difficult task in organic synthesis. Here, we report a general and efficient approach for tackling this problem by gem-difluoroolefination of trifluoroacetaldehyde N-triftosylhydrazone with organoboronic acids. This protocol is operationally simple, free of transition metals, and suitable for a broad range of organoboronic acids. Moreover, the utility of the products was demonstrated by further conversion of the gem-difluorovinyl group.

Activation of 1,1-difluoro-1-alkenes with a transition-metal complex: Palladium(II)-catalyzed friedel - crafts-type cyclization of 4,4-(difluorohomoallyl)arenes

(Chemical Equation Presented) Cationic palladium(II) ([Pd(MeCN) 4](BF4)2) provides the first transition-metal-catalyzed method for electrophilic activation of electron-deficient 1,1-difluoro-1-alkenes, which allows their Friedel-Crafts-type cyclization with an intramolecular aryl group via a Wacker-type process. By using BF3·OEt2, the cyclization was effected by a catalytic amount of the palladium without its reoxidation.

A NOVEL SYNTHESIS OF 1,1-DIFLUOROOLEFINS FROM 1,1,1-TRIFLUOROETHYL p-TOLUENESULFONATE VIA BORONATE-COMPLEX

The nucleophilic substitution of gem-difluorovinylic tosyloxy group with alkyl groups is effected by treating 2,2-difluoro-1-tosyloxyvinyllithium with trialkylboranes to afford 1,1-difluoroolefins in good yields.