1234675-35-4Relevant academic research and scientific papers
Binary-Acid Catalysis with Sc(OTf)3/TfOH in the Alkenylation of Arenes with Alkynes
Zhang, Wenxuan,Sun, Jiaying,Xiang, Linrui,Si, Wen,Song, Ran,Yang, Daoshan,Lv, Jian
supporting information, p. 5998 - 6003 (2021/07/31)
Herein we report binary acid Sc(OTf)3/TfOH-catalyzed alkenylation of arenes with alkynes. In this system, the high-energy vinyl carbocations with activated and weakly coordinating trifluoromethanesulfonate anions by Lewis acid Sc(III) can undergo facile F
Palladium-catalyzed cyclocoupling of 2-halobiaryls with isocyanides via the cleavage of carbon-hydrogen bonds
Tobisu, Mamoru,Imoto, Shinya,Ito, Sana,Chatani, Naoto
supporting information; body text, p. 4835 - 4840 (2010/10/04)
(Figure Presented) To demonstrate the utility of isocyanides in catalytic C-H bond functionalization reactions, a palladium-catalyzed cyclocoupling reaction of 2-halobiaryls with isocyanides was developed. The reaction afforded an array of fluorenone imine derivatives via the cleavage of a C-H bond at the 2′-position of 2-halobiaryls. The use of 2,6-disubstituted phenyl isocyanide was crucial for this catalytic cyclocoupling reaction to proceed. The reaction was applicable to heterocyclic and vinylic substrates, allowing the construction of a wide range of ring system. The large kinetic isotope effect observed (kH/kD = 5.3) indicates that C-H bond activation was the turnover-limiting step in this catalysis.
A New and Convenient Synthesis of Alkyl and Aryl Pyrimidines
Martinez, A. Garcia,Herrera, A.,Martinez, R.,Teso, E.,Garcia, A.,et al.
, p. 1237 - 1241 (2007/10/02)
Vinyl triflates 1, which are obtained easily from the corresponding ketones, react in an excess of pure nitrile (80 deg C/20 hours) to form tri- and tetra-substituted alkyl and arylpyrimidines 4 and 5 in good yields (45-87percent).An isomeric mixture of p
