1234708-04-3

Basic information

• Product Name: N-(3-(5-(2-hydroxypropan-2-yl)-1,2,4-oxadiazol-3-yl)benzyl)-2-(pyridin-2-yl)pyriMidine-5-carboxaMide
• Synonyms: N-(3-(5-(2-hydroxypropan-2-yl)-1,2,4-oxadiazol-3-yl)benzyl)-2-(pyridin-2-yl)pyriMidine-5-carboxaMide;2-(pyridin-2-yl)pyriMidine-5-carboxylic acid 3-[5-(1-hydroxy-1-Methylethyl)-1,2,4]oxadiazol-3-yl-benzylaMide;SAR191801;tert-butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane SAR191801;hPGDS-IN-1;SAR191801,2-Pyridin-2-yl-pyrimidine-5-carboxylic acid 3-[5-(1-hydroxy-1-methyl-ethyl)-[1,2,4]oxadiazol-3-yl]-benzylamide;N-[[3-[5-(1-Hydroxy-1-methylethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-2-(2-pyridinyl)-5-pyrimidinecarboxamide;EOS-61636
• CAS NO: 1234708-04-3
• Molecular Formula: C₂₂H₂₀N₆O₃
• Molecular Weight: 416.4326
• EINECS: -0
• Product Categories: Inhibitors
• Mol File: 1234708-04-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(3-(5-(2-hydroxypropan-2-yl)-1,2,4-oxadiazol-3-yl)benzyl)-2-(pyridin-2-yl)pyriMidine-5-carboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-(5-(2-hydroxypropan-2-yl)-1,2,4-oxadiazol-3-yl)benzyl)-2-(pyridin-2-yl)pyriMidine-5-carboxaMide(1234708-04-3)
• EPA Substance Registry System: N-(3-(5-(2-hydroxypropan-2-yl)-1,2,4-oxadiazol-3-yl)benzyl)-2-(pyridin-2-yl)pyriMidine-5-carboxaMide(1234708-04-3)

Safety Data

• Hazardous Substances Data: 1234708-04-3(Hazardous Substances Data)

Usage

Uses

SAR191801 is a novel hematopoietic prostaglandin D synthase (hPGDS) inhibitor.

Upstream product

• 24964-64-5 3-Cyanobenzaldehyde 
• 220324-83-4 2-[(3-cyanophenyl)methyl]imidodicarbonic acid 1,3-bis(1,1-dimethylethyl) ester 
• 28188-41-2 m-(bromomethyl)benzonitrile 
• 1286182-69-1 3-[5-(1-hydroxy-1-methyl-ethyl)-[1,2,4]oxadiazol-3-yl]benzyl-amine hydrochloride 
• 933988-22-8 2-(pyridin-2-yl)pyrimidine-5-carboxylic acid 
• 1286182-70-4 3-[5-(1-hydroxy-1-methyl-ethyl)-[1,2,4]oxadiazol-3-yl]benzyl-amine 
• 1068976-90-8 methyl 2-(pyridin-2-yl)pyrimidine-5-carboxylate 
• 220324-85-6 2-[[3-[(hydroxyamino)iminomethyl]phenyl]methyl]imidodicarbonic acid 1,3-bis(1,1-dimethylethyl) ester 
• 1256486-34-6 N-hydroxy-3-(hydroxyiminomethyl)benzamidine 
• 1286182-73-7 3-[5-(1-hydroxy-1-methylethyl)-[1,2,4]oxadiazol-3-yl]benzaldehyde oxime 
• 1286182-76-0 2-[3-(3-aminomethylphenyl)-[1,2,4]-oxadiazol-5-yl]-propan-2-ol acetate 
• 1286182-78-2 3-[5-(1-hydroxy-1-methylethyl)-[1,2,4]oxadiazol-3-yl]benzyl-carbamic acid tert-butyl ester 

Relevant articles and documents

Demonstration on pilot-plant scale of the utility of 1,5,7-triazabicyclo[4. 4.0]dec-5-ene (TBD) as a catalyst in the efficient amidation of an unactivated methyl ester

The utility of 1,5,7-triazabicyclo[4.4.0]dec-5-ene as a reagent to facilitate efficient amide formation by reaction of an amine with an unactivated ester was demonstrated on pilot-plant scale as a key step in the synthesis of an H-PGDS inhibitor.

PHENYLOXADIAZOLE DERIVATIVES AS PGDS INHIBITORS

This invention is directed to a compound of formula (I): wherein R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising the compound, intermediates and processes for making said compounds, and the use of the compound to treat allergi