123474-55-5

Upstream product

• 71387-05-8 4-methoxy-3-bromo-furan-2(5H)-one 
• 98-88-4 benzoyl chloride 
• 386280-22-4 (RS)-3-(1-hydroxybenzyl)-4-methoxyfuran-2(5H)-one 
• 69556-70-3 4-methoxy-5H-furan-2-one 
• 871130-22-2 (3-iodo-4-methoxy-furan-2-yloxy)-triisopropyl-silane 
• 123474-54-4 O-methyl 3-(tri-n-butylstannyl)tetronate 
• 169385-32-4 3-iodo-4-methoxy-5H-furan-2-one 

Relevant academic research and scientific papers

Highly regioselective 3-hydroxyalkylations of boron 4-methoxy-2-furanolates: A new entry to 5-unsubstituted and 5-monosubstituted 3-acyl-4-o-methyl tetronates

Boron 4-methoxy-2-furanolates generated in situ from 5-unsubstituted and 5-monosubstituted 4-O-methyl tetronates undergo highly regioselective 3-hydroxyalkylations with aldehydes to give 5-unsubstituted and 5-monosubstituted 3-acyl-4-O-methyl tetronates, respectively, in good overall yields after oxidation of the intermediate alcohols with 2-iodoxybenzoic acid.

A general method for the highly regioselective introduction of substituents into the 3-position of 5-unsubstituted 4-O-alkyl tetronates

A new, general method for the highly regioselective introduction of substituents into the 3-position of 5-unsubstituted 4-O-alkyl tetronates has been developed. 3-Lithiated 4-alkoxy-2-triisopropylsilyloxyfurans generated from the corresponding 3-iodoprecursors via halogen-metal exchange serve as key intermediates. Georg Thieme Verlag Stuttgart.

The Total Synthesis of Agglomerin A and (+/-)-Carolinic Acid. A General Method for the Preparation of 3-Acyl Tetronic Acids Via Direct Acylation of O-Methyl 3-Stannyl Tetronates

A variety of O-methyl-3-acyl tetronates were prepared in good yield from the corresponding acid chlorides via a palladium catalyzed acylation of O-methyl 3-(tri-n-butylstannyl) tetronate 5.This new synthetic method was the exploited for the total synthesis of the novel antibiotic agglomerin A 3a, as well as the fungal metabolite (+/-)-carolinic acid 15.