1234804-85-3Relevant academic research and scientific papers
An enantioselective formal synthesis of (+)-Gephyrotoxin 287C
Miao, Lei,Shu, Hong,Noble, April R.,Fournet, Steven P.,Stevens, Edwin D.,Trudell, Mark L.
, p. 6 - 14 (2012/10/30)
The tricyclic skeleton of the gephyrotoxin amphibian alkaloids was synthesized via an enantioselective serial sequence involving nine discrete steps that furnished Kishi's intermediate 5 in 22% overall yield. This efficient and expeditious synthetic approach exploits the inherent stereochemistry of a (1R)-2-tropinone derivative for the construction of the core cis-2,5-disubstituted pyrrolidine ring system and constitutes a formal synthesis of gephyrotoxin 287C. ARKAT USA, Inc.
